High affinity inhibitors of the dopamine transporter (DAT): Novel biotinylated ligands for conjugation to quantum dots

被引：21
作者：
Tomlinson, Ian D.
Mason, John N.
Blakely, Randy D.
Rosenthal, Sandra J.
机构：
[1] Vanderbilt Univ, Dept Chem, Nashville, TN 37235 USA
[2] Vanderbilt Univ, Sch Med, Dept Pharmacol, Nashville, TN 37232 USA
[3] Vanderbilt Univ, Sch Med, Vanderbilt Ctr Mol Neurosci, Nashville, TN 37232 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 17期
关键词：
dopamine transporter; quantum dot; cadmium selenide; reuptake inhibitor; FLUORESCENT NANOCRYSTALS; LONG-TERM; RECEPTORS; DERIVATIVES; DESIGN; CELLS; DNA;
D O I：
10.1016/j.bmcl.2006.05.097
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Compounds capable of inhibiting the dopamine transporter protein (DAT) that can be conjugated to cadmium selenide/zinc sulfide/core shell nanocrystals may be used to image the location and distribution of the DAT in neuronal cell membranes. This letter describes the synthesis of biotinylated analogs of the DAT antagonists GBR 12909 and GBR 12935 that can be attached to streptavidin coated cadmium selenide/zinc sulfide/core shell nanocrystals. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4664 / 4667
页数：4
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