Polycyclic N-Heterocyclic Compounds 76: Synthesis and Antiplatelet Evaluation of 2,4-Disubstituted 5,6-Dihydro[1]benzofuro[3',2':2,3]oxepino[4,5-d]pyrimidines
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作者:
Okuda, Kensuke
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Gifu Pharmaceut Univ, Lab Med & Pharmaceut Chem, Gifu 5011196, JapanGifu Pharmaceut Univ, Lab Med & Pharmaceut Chem, Gifu 5011196, Japan
Okuda, Kensuke
[1
]
Takano, Jun-ichi
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机构:
Okayama Univ, Fac Pharmaceut Sci, Lab Pharmaceut Chem, Kita Ku, Okayama 7008530, JapanGifu Pharmaceut Univ, Lab Med & Pharmaceut Chem, Gifu 5011196, Japan
Takano, Jun-ichi
[2
]
Hirota, Takashi
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Okayama Univ, Fac Pharmaceut Sci, Lab Pharmaceut Chem, Kita Ku, Okayama 7008530, JapanGifu Pharmaceut Univ, Lab Med & Pharmaceut Chem, Gifu 5011196, Japan
Hirota, Takashi
[2
]
Sasaki, Kenji
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Okayama Univ, Fac Pharmaceut Sci, Lab Pharmaceut Chem, Kita Ku, Okayama 7008530, JapanGifu Pharmaceut Univ, Lab Med & Pharmaceut Chem, Gifu 5011196, Japan
Sasaki, Kenji
[2
]
Nishina, Yuta
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Okayama Univ, Res Core Interdisciplinary Sci, Kita Ku, Okayama 7008530, JapanGifu Pharmaceut Univ, Lab Med & Pharmaceut Chem, Gifu 5011196, Japan
Nishina, Yuta
[3
]
Ishida, Hiroyuki
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Okayama Univ, Dept Chem, Fac Sci, Kita Ku, Okayama 7008530, JapanGifu Pharmaceut Univ, Lab Med & Pharmaceut Chem, Gifu 5011196, Japan
Ishida, Hiroyuki
[4
]
机构:
[1] Gifu Pharmaceut Univ, Lab Med & Pharmaceut Chem, Gifu 5011196, Japan
[2] Okayama Univ, Fac Pharmaceut Sci, Lab Pharmaceut Chem, Kita Ku, Okayama 7008530, Japan
[3] Okayama Univ, Res Core Interdisciplinary Sci, Kita Ku, Okayama 7008530, Japan
[4] Okayama Univ, Dept Chem, Fac Sci, Kita Ku, Okayama 7008530, Japan
Reaction of several Vilsmeier reagents with 5-amino-2,3-dihydro[1]benzofuro[3,2-b]oxepin-4-carbonitrile gave tetracyclic 2-substituted 4-chloro-5,6-dihydro[1] benzofuro[3',2':2,3]oxepino[4,5-d]pyrimidines. The structure of one of these, the 4-chloro-2-phenyl derivative, was confirmed by X-ray crystallography. Treatment of the 4-chloro derivatives with simple amines as nucleophile afforded 2-substituted 4-amino derivatives. A pentacyclic compound was also obtained by dehydrative ring closure. These products were evaluated for antiplatelet activity, and some showed potency comparable with that of aspirin.
机构:
Gifu Pharmaceut Univ, Lab Med & Pharmaceut Chem, Gifu 5011196, JapanGifu Pharmaceut Univ, Lab Med & Pharmaceut Chem, Gifu 5011196, Japan
Okuda, Kensuke
Takarada, Shigeki
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Okayama Univ, Fac Pharmaceut Sci, Lab Pharmaceut Chem, Kita Ku, Okayama 7008530, JapanGifu Pharmaceut Univ, Lab Med & Pharmaceut Chem, Gifu 5011196, Japan
Takarada, Shigeki
Hirota, Takashi
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机构:
Okayama Univ, Fac Pharmaceut Sci, Lab Pharmaceut Chem, Kita Ku, Okayama 7008530, JapanGifu Pharmaceut Univ, Lab Med & Pharmaceut Chem, Gifu 5011196, Japan
Hirota, Takashi
Sasaki, Kenji
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机构:
Okayama Univ, Fac Pharmaceut Sci, Lab Pharmaceut Chem, Kita Ku, Okayama 7008530, JapanGifu Pharmaceut Univ, Lab Med & Pharmaceut Chem, Gifu 5011196, Japan
机构:
Gifu Pharmaceut Univ, Lab Med & Pharmaceut Chem, Gifu 5011196, JapanGifu Pharmaceut Univ, Lab Med & Pharmaceut Chem, Gifu 5011196, Japan
Okuda, Kensuke
Hirota, Takashi
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机构:
Okayama Univ, Fac Pharmaceut Sci, Lab Pharmaceut Chem, Kita Ku, Okayama 7008530, JapanGifu Pharmaceut Univ, Lab Med & Pharmaceut Chem, Gifu 5011196, Japan
Hirota, Takashi
Sasaki, Kenji
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h-index: 0
机构:
Okayama Univ, Fac Pharmaceut Sci, Lab Pharmaceut Chem, Kita Ku, Okayama 7008530, JapanGifu Pharmaceut Univ, Lab Med & Pharmaceut Chem, Gifu 5011196, Japan
机构:
Gifu Pharmaceut Univ, Lab Med & Pharmaceut Chem, Gifu 5011196, JapanGifu Pharmaceut Univ, Lab Med & Pharmaceut Chem, Gifu 5011196, Japan
Okuda, Kensuke
Takano, Jun-ichi
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h-index: 0
机构:
Okayama Univ, Fac Pharmaceut Sci, Lab Pharmaceut Chem, Kita Ku, Okayama 7008530, JapanGifu Pharmaceut Univ, Lab Med & Pharmaceut Chem, Gifu 5011196, Japan
Takano, Jun-ichi
Hirota, Takashi
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h-index: 0
机构:
Okayama Univ, Fac Pharmaceut Sci, Lab Pharmaceut Chem, Kita Ku, Okayama 7008530, JapanGifu Pharmaceut Univ, Lab Med & Pharmaceut Chem, Gifu 5011196, Japan
Hirota, Takashi
Sasaki, Kenji
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h-index: 0
机构:
Okayama Univ, Fac Pharmaceut Sci, Lab Pharmaceut Chem, Kita Ku, Okayama 7008530, JapanGifu Pharmaceut Univ, Lab Med & Pharmaceut Chem, Gifu 5011196, Japan