Elevated serum progesterone level on the day of human chorionic gonadotropin administration does not adversely affect implantation rates after intracytoplasmic sperm injection and embryo transfer

被引:70
|
作者
Urman, B [1 ]
Alatas, C [1 ]
Aksoy, S [1 ]
Mercan, R [1 ]
Isiklar, A [1 ]
Balaban, B [1 ]
机构
[1] Amer Hosp Istanbul, Assisted Reprod Unit, Istanbul, Turkey
关键词
progesterone; fertilization in vitro; intracytoplasmic sperm injection; implantation;
D O I
10.1016/S0015-0282(99)00421-5
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To evaluate the association between serum P levels on the day of hCG administration and the outcome of intracytoplasmic sperm injection (ICSI). Design: Retrospective case study. Setting: Assisted reproduction unit of a tertiary care private hospital. Patient(s): Nine hundred eleven ICSI cycles that proceeded to ET were studied. Intervention(s): The decision to administer hCG was based on serum E-2 levels and follicle size. Serum P was measured from frozen sera obtained on the day of hCG administration. Cycles were stratified according to serum P levels of <0.9 ng/mL (n = 298) or greater than or equal to 0.9 ng/mL (n = 613). This cutoff level was selected because it yielded the highest sensitivity and specificity according to a receiver operator characteristic curve. Main Outcome Measure(s): Implantation and clinical pregnancy rates. Result(s): In cycles with high serum P levels, more oocytes were retrieved and more embryos were available for transfer. Clinical pregnancy rates per ET in the low and high P groups were 36.9% and 45.4%, respectively (P<.05). The implantation rate per embryo was similar in the two groups (14.9% and 16.4%, respectively, in cycles with P levels <0.9 vs greater than or equal to 0.9 ng/mL). Abortion rates were 22.7 and 25.8%, respectively (P>.05). Conclusion(s): Our data showed no adverse effect of high serum P levels on the day of hCG administration on implantation rates after ICSI and ET. ((C)1999 by American Society for Reproductive Medicine.).
引用
收藏
页码:975 / 979
页数:5
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