Association of serum BPA levels with changes in lipid levels and dyslipidemia risk in middle-aged and elderly Chinese

被引:14
作者
Yao, Jinqiu [1 ]
Wang, Fei [2 ]
Zhang, Ying [1 ]
Zhang, Zefang [1 ]
Bi, Jiao [1 ]
He, Jia [3 ]
Li, Peiwen [1 ]
Han, Xu [1 ]
Wei, Yue [1 ]
Zhang, Xiaomin [1 ]
Guo, Huan [1 ]
He, Meian [1 ,4 ,5 ]
机构
[1] Huazhong Univ Sci & Technol, Sch Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, Wuhan, Hubei, Peoples R China
[2] Guangxi Med Univ, Sch Publ Hlth, Dept Occupat Hlth & Environm Hlth, Nanning 530021, Guangxi, Peoples R China
[3] Shihezi Univ, Dept Publ Hlth, Sch Med, Shihezi 832000, Xinjiang, Peoples R China
[4] Huazhong Univ Sci & Technol, Dept Occupat & Environm Hlth, Key Lab Environm & Hlth, Minist Educ, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China
[5] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth Incubating, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China
基金
中国国家自然科学基金;
关键词
Bisphenol A; Dyslipidemia; Lipid metabolism; Prospective study; URINARY BISPHENOL-A; EXPOSURE; HYPERCHOLESTEROLEMIA; CHOLESTEROL; PREVALENCE; METABOLISM; AWARENESS; ADULTS; HEALTH;
D O I
10.1016/j.ecoenv.2022.113819
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Previous evidences exploring the associations of BPA with lipid changes and dyslipidemia did not obtain consistent results. To evaluate whether serum BPA concentration was associated with changes in blood lipid levels and incident dyslipidemia risk in middle-elderly Chinese adults, we conducted a prospective study with 1093 participants (average 62.65 years old) derived from the Dongfeng-Tongji cohort which was founded in 2008 and followed up each 5 years. Serum BPA levels were measured by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS). Changes in lipid levels were named as Delta lipids which equal to Lipid2013 -Lipid2008. The diagnosis of dyslipidemia was according to Chinese Guidelines on Prevention and Treatment of Dyslipidemia in 2016. We used multivariable linear regression and Logistic regression to explore the relations between serum BPA levels and changes in lipid levels and incident dyslipidemia risk, respectively. Besides, restricted cubic splines were used to explore the dose-response relations. After 5 years' follow-up, 51 individuals developed with hypercholesterolemia, 87 with hypertriglyceridemia, 34 with high-LDL-cholesterolemia, 74 with low-HDL-cholesterolemia, and 199 with dyslipidemia. At baseline serum BPA levels were positively related to TC, LDL-c, and Non-HDL-c levels. In the prospective study, each Ln-BPA increase was associated with 0.05 (95% CI: 0.02, 0.09) mmol/L increase in Delta TC, 0.07 (95% CI:0.03, 0.11) mmol/L in-crease in Delta Non-HDL-c, 0.05 (95% CI: 0.01, 0.08) increase in Delta TC/HDL-c, and 0.05 (95% CI: 0.01, 0.08) increase in Delta Non-HDL-c/HDL-c. We only observed significant associations in females but not in males. Besides, serum BPA levels were positively associated with hypercholesterolemia (OR=1.12, 95% CI: 1.01, 1.25). The restricted cubic splines obtained similar results. In conclusion, serum BPA was associated TC and Non-HDL-c changes, and BPA was also associated with increased risk of hypertriglyceridemia. Further prospective studies with large sample size are warranted to validate our findings.
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页数:9
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