Anti-human immunodeficiency and anti-hepatitis B virus activities of beta-L-2',3'-dideoxy purine nucleosides

被引：54
作者：
Bolon, PJ
Wang, PY
Chu, CK
Gosselin, G
Boudou, V
Pierra, C
Mathe, C
Imbach, JL
Faraj, A
Alaoui, MA
Sommadossi, JP
Pai, SB
Zhu, YL
Lin, JS
Cheng, YC
Schinazi, RF
机构：
[1] UNIV GEORGIA,COLL PHARM,DEPT MED CHEM,ATHENS,GA 30602
[2] UNIV MONTPELLIER 2,CHIM BIOORGAN LAB,UMR CNRS 5625,F-34095 MONTPELLIER,FRANCE
[3] UNIV ALABAMA,SCH MED,DEPT PHARMACOL,BIRMINGHAM,AL 35294
[4] YALE UNIV,SCH MED,DEPT PHARMACOL,NEW HAVEN,CT 06510
[5] EMORY UNIV,SCH MED,VET ADM MED CTR,DEPT PEDIAT,DECATUR,GA 30033
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 14期
关键词：
D O I：
10.1016/0960-894X(96)00293-4
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
beta-L-2',3'-Dideoxyadenosine, beta-L-2',3'-didehydro-2',3'-dideoxyadenosine and related compounds were synthesized in a stereoselective manner. These compounds were tested in vitro against HBV in 2.2.15 cell line and against HIV-1 in PBM and CEM cells. It was found that beta-L-2',3'-didehydro-2',3'-dideoxyadenosine (7) exhibited significant anti-HIV (EC(50) 0.38 mu M in PBM cells) and anti-HBV activity (EC(50) 1.2 mu M). Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码：1657 / 1662
页数：6
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