Modulatory role of GSTT1 and GSTM1 in Punjabi agricultural workers exposed to pesticides

被引：8

作者：

Ahluwalia, Meenakshi ^{[1
]}

Kaur, Anupam ^{[1
]}

机构：

[1] Guru Nanak Dev Univ, Dept Human Genet, Amritsar, Punjab, India

来源：

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH | 2018年 / 25卷 / 12期

关键词：

Glutathione S-transferases; GSTT1; GSTM1; Xenobiotics; Pesticides; Agriculture; GLUTATHIONE S-TRANSFERASES; GENETIC POLYMORPHISMS; OCCUPATIONAL-EXPOSURE; ORGANOPHOSPHATE PESTICIDES; BLADDER-CANCER; DNA-DAMAGE; POPULATION; RISK; SUSCEPTIBILITY; HEALTH;

D O I：

10.1007/s11356-018-1459-7

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Glutathione S-transferases are important detoxification enzymes involved in the metabolism of endogenous as well as exogenous compounds. Individuals differ in metabolic capacity due to inherited genetic variations. Due to the polymorphism exhibited by GSTT1 and GSTM1 that results in the complete loss of function, the present study was aimed towards the determination of the frequency distribution of GSTT1 and GSTM1 in agricultural workers in Punjab, India. The study aimed to investigate their contribution in susceptibility to increased disease risk. A total of 513 subjects were included in this study, out of which 250 were agriculture workers and 263 were non-exposed occupationally. GSTT1 and GSTM1 null-genotype distribution was analyzed through multiplex-PCR method. Complete gene deletion in either of the genes was strongly associated with an increased risk (OR = 1.8; 95% CI = 1.3-2.6; p < 0.0008) of DNA/cytogenetic damage, cancer, infertility, and many other serious health effects. Therefore, homozygous deletion in GSTT1 or GSTM1 could play a modulatory role in health of workers with long-term exposure to pesticides.

引用

页码：11981 / 11986

页数：6

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