Modifications and functional genomics of human transfer RNA

被引：278

作者：

Pan, Tao ^{[1
]}

机构：

[1] Univ Chicago, Dept Biochem & Mol Biol, 920 E 58Th St, Chicago, IL 60637 USA

来源：

CELL RESEARCH | 2018年 / 28卷 / 04期

关键词：

MITOCHONDRIAL TRANSFER-RNAS; CODON-USAGE; SACCHAROMYCES-CEREVISIAE; SEQUENCING REVEALS; CANCER PROGRESSION; MASS-SPECTROMETRY; PROTEIN-SYNTHESIS; GENE-EXPRESSION; CELLULAR STRESS; REPEAT PROTEIN;

D O I：

10.1038/s41422-018-0013-y

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Transfer RNA (tRNA) is present at tens of millions of transcripts in a human cell and is the most abundant RNA in moles among all cellular RNAs. tRNA is also the most extensively modified RNA with, on an average, 13 modifications per molecule. The primary function of tRNA as the adaptor of amino acids and the genetic code in protein synthesis is well known. tRNA modifications play multi-faceted roles in decoding and other cellular processes. The abundance, modification, and aminoacylation (charging) levels of tRNAs contribute to mRNA decoding in ways that reflect the cell type and its environment; however, how these factors work together to maximize translation efficiency remains to be understood. tRNAs also interact with many proteins not involved in translation and this may coordinate translation activity and other processes in the cell. This review focuses on the modifications and the functional genomics of human tRNA and discusses future perspectives on the explorations of human tRNA biology.

引用

页码：395 / 404

页数：10

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