Copper activity against multiresistant Gram-positive cocci isolated in Chilean hospitals

被引：1

作者：

Kappes, Tomas ^{[1
]}

Dominguez, Mariana ^{[1
]}

Bello-Toledo, Helia ^{[1
]}

Montecinos, Sergio Melia ^{[2
,3
]}

Molina, Gisella Riedel ^{[2
]}

Gonzalez-Rocha, Gerardo ^{[1
]}

机构：

[1] Univ Concepcion, Fac Ciencias Biol, Dept Microbiol, Lab Invest Agentes Antibacterianos, Concepcion, Chile

[2] Univ Concepcion, Fac Med, Dept Med Interna, Concepcion, Chile

[3] Hosp Reg Dr Guillermo Grant Benavente, Unidad Infectol, Concepcion, Chile

来源：

REVISTA CHILENA DE INFECTOLOGIA | 2016年 / 33卷 / 05期

关键词：

Copper tolerance; antibiotic resistance; nosocomial infections; RESISTANT STAPHYLOCOCCUS-AUREUS; SURFACES; CASSETTE;

D O I：

10.4067/S0716-10182016000500005

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background: Nosocomial infections caused by multiresistant Gram-positive cocci are a serious problem for public health systems worldwide. The use of copper surfaces in hospital environments has proven to be an effective alternative for the control of various microorganisms, including multiresistant nosocomial pathogens. Aim: To determine the association between antibiotic multiresistance and higher levels of copper tolerance in Gram-positive cocci isolated from Chilean hospitals, which might confer a selective advantage in environments with copper. Methods: The ionic copper tolerance levels were evaluated using the Mueller Hinton agar dilution method, in S. aureus and Enterococcus spp. strains with different levels of susceptibility to clinically relevant antibiotics. Results: A statistically significant association between higher levels of tolerance to copper ion and multi-resistance to antibiotics in Enterococcus spp. was observed.

引用

页码：519 / 523

页数：5

共 21 条

[1]

[Anonymous], INF VIG INF AS AT SA

[2]

[Anonymous], 2013, M02A11 CLSI

[3] The Staphylococcus aureus CsoR regulates both chromosomal and plasmid-encoded copper resistance mechanisms [J].

Baker, Jonathan ;

Sengupta, Mrittika ;

Jayaswal, Radheshyan K. ;

Morrissey, Julie A. .

ENVIRONMENTAL MICROBIOLOGY, 2011, 13 (09) :2495-2507

[4]

Clinical and Laboratory Standards Institute, 2013, M07A9 CLSI

[5] Genes involved in copper resistance influence survival of Pseudomonas aeruginosa on copper surfaces [J].

Elguindi, J. ;

Wagner, J. ;

Rensing, C. .

JOURNAL OF APPLIED MICROBIOLOGY, 2009, 106 (05) :1448-1455

[6] Advantages and challenges of increased antimicrobial copper use and copper mining [J].

Elguindi, Jutta ;

Hao, Xiuli ;

Lin, Yanbing ;

Alwathnani, Hend A. ;

Wei, Gehong ;

Rensing, Christopher .

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2011, 91 (02) :237-249

[7] The ecology, epidemiology and virulence of Enterococcus [J].

Fisher, Katie ;

Phillips, Carol .

MICROBIOLOGY-SGM, 2009, 155 :1749-1757

[8] Metallic Copper as an Antimicrobial Surface [J].

Grass, Gregor ;

Rensing, Christopher ;

Solioz, Marc .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2011, 77 (05) :1541-1547

[9] tcrB, a gene conferring transferable copper resistance in Enterococcus faecium:: Occurrence, transferability, and linkage to macrolide and glycopeptide resistance [J].

Hasman, H ;

Aarestrup, FM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (05) :1410-1416

[10] Copper activity against multiresistant Gram negative bacilli isolated from Chilean hospitals [J].

Kappes, Tomas ;

Dominguez, Mariana ;

Bello, Helia ;

Mella, Sergio ;

Riedel, Gisela ;

Gonzalez-Rocha, Gerardo .

REVISTA CHILENA DE INFECTOLOGIA, 2012, 29 (06) :622-627

← 1 2 3 →