Pregnant women's cognitive appraisal of a natural disaster affects their children's BMI and central adiposity via DNA methylation: Project Ice Storm

被引：29

作者：

Cao-Lei, Lei ^{[1
,2
]}

Dancause, Kelsey N. ^{[3
]}

Elgbeili, Guillaume ^{[4
]}

Laplante, David P. ^{[4
]}

Szyf, Moshe ^{[5
,6
]}

King, Suzanne ^{[1
,2
]}

机构：

[1] McGill Univ, Dept Psychiat, Montreal, PQ, Canada

[2] Douglas Hosp, Res Ctr, Psychosocial Res Div, Montreal, PQ, Canada

[3] Univ Quebec Montreal, Dept Kinanthropol, Montreal, PQ, Canada

[4] Douglas Hosp, Res Ctr, Psychosocial Res Div, Montreal, PQ, Canada

[5] McGill Univ, Dept Pharmacol & Therapeut, Montreal, PQ, Canada

[6] McGill Univ, Sackler Program Epigenet & Dev Psychobiol, Montreal, PQ, Canada

来源：

EARLY HUMAN DEVELOPMENT | 2016年 / 103卷

关键词：

PRENATAL MATERNAL STRESS; ALPHA GENE; EXPOSURE; HEALTH; CHILDHOOD; OBESITY; RISK;

D O I：

10.1016/j.earlhumdev.2016.09.013

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

We determined the extent to which DNA methylation mediates the effects of maternal cognitive appraisal of a natural disaster during pregnancy on offspring growth at age 13. Negative maternal cognitive appraisal predicted both lower BMI and central adiposity via DNA methylation of diabetes-related genes, suggesting a protective role of epigenetics. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：189 / 192

页数：4

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