Microarray analysis of altered long non-coding RNA expression profile in liver cancer cells treated by ginsenoside Rh2

被引：12

作者：

Chen, Wei-Wen ^{[1
]}

Huang, Ying-Feng ^{[1
]}

Hu, Zhi-Bing ^{[1
]}

Liu, Yi-Min ^{[1
]}

Xiao, Hong-Xia ^{[1
]}

Liu, Da-Bin ^{[1
]}

Zhuang, Ying-Zi ^{[1
]}

机构：

[1] Guangzhou Twelfth Peoples Hosp, Med Labs, Guangzhou 510620, Guangdong, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2019年 / 21卷 / 08期

关键词：

Long non-coding RNA; ginsenoside Rh2; hepatocellular carcinoma; HepG2; gene expression profile; HEPATOCELLULAR-CARCINOMA; THERAPY; GROWTH; MODEL;

D O I：

10.1080/10286020.2018.1490273

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Microarray expression profiles of lncRNAs and mRNAs were investigated in HepG2 cells treated with 20 mu g/ml ginsenoside Rh2 as well as in ginsenoside Rh2-untreated cells. Microarray analysis showed 618 upregulated lncRNAs and 161 downregulated lncRNAs in HepG2 cells treated with ginsenoside Rh2 compared with the control group. Moreover, three differentially expressed lncRNAs were validated by quantitative real-time polymerase chain reaction (qRT-PCR). This may be beneficial to patients as an anti-cancer treatment and potentially provide novel targets for HCC (hepatocellular carcinoma) therapy. [GRAPHICS] .

引用

页码：742 / 753

页数：12

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