InCl3-mediated eco-friendly three-component domino reaction for synthesis of highly functionalized triazolylspiroxindolinopyrans and triazolylpyrans under solvent-free conditions

被引：14
|
作者：
Kamalraja, Jayabal [1 ]
Murugasan, Potharaj [1 ]
Perumal, Paramasivan Thirumalai [1 ]
机构：
[1] CSIR, Cent Leather Res Inst, Div Organ Chem, Madras 600020, Tamil Nadu, India
来源：
RSC ADVANCES | 2014年 / 4卷 / 37期
关键词：
DIELS-ALDER REACTIONS; CATALYTIC ASYMMETRIC-SYNTHESIS; CELL CYCLE INHIBITORS; ONE-POT SYNTHESIS; EFFICIENT SYNTHESIS; ORGANIC-SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; ASPERGILLUS-FUMIGATUS; CLICK CHEMISTRY; ATOM ECONOMY;
D O I：
10.1039/c4ra01524j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A one pot domino protocol has been developed for the efficient synthesis of novel triazolylspiroxindolinopyrans and triazolylpyran derivatives. The synthesis was achieved by reacting phenacyltriazole, isatin/aromatic aldehyde and active methylene compounds in the presence of InCl3 under solvent-free conditions at 100 degrees C. This novel strategy affording biologically relevant heterocyclic compounds presumably involves Knoevenagel condensation/Michael addition/6-exo-dig-cyclisation sequences.
引用
收藏
页码：19422 / 19432
页数：11
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