Iodine-catalyzed one-pot synthesis and antimalarial activity evaluation of symmetrically and asymmetrically substituted 3,6-diphenyl[1,2,4,5] tetraoxanes

被引：45

作者：

Kumar, Nitin ^{[1
]}

Khan, Shabana I. ^{[2
]}

Sharma, Mukul ^{[1
]}

Atheaya, Himanshu ^{[1
]}

Rawat, Diwan S. ^{[1
]}

机构：

[1] Univ Delhi, Dept Chem, Delhi 110007, India

[2] Univ Mississippi, Natl Ctr Nat Prod Res, University, MS 38677 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 06期

关键词：

Plasmodium falciparum; Artemisinin; Tetraoxane; QINGHAOSU ARTEMISININ; CARBONYL-COMPOUNDS; CYCLIC PEROXIDES; 1,2,4,5-TETRAOXANES; 1,2,4,5-TETROXANES; CHEMISTRY; DRUG; 1,2,4,5,7-PENTOXOCANES; DIHYDROPEROXIDES; OZONOLYSIS;

D O I：

10.1016/j.bmcl.2009.01.103

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel iodine-catalyzed one-pot synthesis of symmetrically and asymmetrically substituted 3,6-diphenyl[1,2,4,5] tetraoxanes is described. The synthetic protocol is general with substituted benzaldehydes and proceeds well under acidic conditions. Total 17 tetraoxanes have been prepared during this study and some of these compounds exhibit promising antimalarial activity. None of the compounds shows any toxicity against vero cells. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1675 / 1677

页数：3

共 36 条

[1] ONE ELECTRON-TRANSFER CHAIN DECOMPOSITION OF TRIFLUOROACETONE DIPEROXIDE - THE 1ST 1,2,4,5-TETROXANE WITH O-TRANSFER CAPABILITY [J].