Fear Memory Recall Potentiates Opiate Reward Sensitivity through Dissociable Dopamine D1 versus D4 Receptor-Dependent Memory Mechanisms in the Prefrontal Cortex

被引:22
作者
Li, Jing Jing [1 ]
Szkudlarek, Hanna [1 ]
Renard, Justine [1 ]
Hudson, Roger [1 ,2 ]
Rushlow, Walter [1 ,2 ]
Laviolette, Steven R. [1 ,2 ]
机构
[1] Univ Western Ontario, Schulich Sch Med & Dent, Dept Anat & Cell Biol, London, ON N6A 5C1, Canada
[2] Univ Western Ontario, Schulich Sch Med & Dent, Dept Psychiat, London, ON N6A 5C1, Canada
基金
加拿大健康研究院;
关键词
dopamine; fear memory; opioids; prefrontal cortex; PTSD; ventral tegmental area; POSTTRAUMATIC-STRESS-DISORDER; SIGNAL-REGULATED KINASE; BASOLATERAL AMYGDALA; PRELIMBIC CORTEX; DIFFERENTIALLY MODULATE; HOMEOSTATIC REGULATION; EMOTIONAL MEMORY; HEROIN; TRANSMISSION; POLYMORPHISM;
D O I
10.1523/JNEUROSCI.3113-17.2018
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Disturbances in prefrontal cortical (PFC) dopamine (DA) transmission are well established features of psychiatric disorders involving pathological memory processing, such as post-traumatic stress disorder and opioid addiction. Transmission through PFC DA D4 receptors (D4Rs) has been shown to potentiate the emotional salience of normally nonsalient emotional memories, whereas transmission through PFC DA D1 receptors (D1Rs) has been demonstrated to selectively block recall of reward-or aversion-related associative memories. In the present study, using a combination of fear conditioning and opiate reward conditioning in male rats, we examined the role of PFC D4/D1R signaling during the processing of fear-related memory acquisition and recall and subsequent sensitivity to opiate reward memory formation. We report that PFC D4R activation potentiates the salience of normally subthreshold fear conditioning memory cues and simultaneously potentiates the rewarding effects of systemic or intra-ventral tegmental area (VTA) morphine conditioning cues. In contrast, blocking the recall of salient fear memories with intra-PFC D1R activation, blocks the ability of fear memory recall to potentiate systemic or intra-VTA morphine place preference. These effects were dependent upon dissociable PFC phosphorylation states involving calcium-calmodulin-kinase II or extracellular signal-related kinase 1-2, following intra-PFC D4 or D1Ractivation, respectively. Together, these findings reveal new insights into how aberrant PFC DAergic transmission and associated downstream molecular signaling pathways may modulate fear-related emotional memory processing and concomitantly increase opioid addiction vulnerability.
引用
收藏
页码:4543 / 4555
页数:13
相关论文
共 56 条
[1]   Interaction Effect of D4 Dopamine Receptor Gene and Serotonin Transporter Promoter Polymorphism on the Cortisol Stress Response [J].
Armbruster, D. ;
Mueller, A. ;
Moser, D. A. ;
Lesch, K. P. ;
Brocke, B. ;
Kirschbaum, C. .
BEHAVIORAL NEUROSCIENCE, 2009, 123 (06) :1288-1295
[2]   DRD4 genotype moderates the impact of parental problems on unresolved loss or trauma [J].
Bakermans-Kranenburg, Marian J. ;
van IJzendoorn, Marinus H. ;
Caspers, Kristin ;
Philibert, Robert .
ATTACHMENT & HUMAN DEVELOPMENT, 2011, 13 (03) :253-269
[3]   Non-medical use of prescription opioids is associated with heroin initiation among US veterans: a prospective cohort study [J].
Banerjee, Geetanjoli ;
Edelman, E. Jennifer ;
Barry, Declan T. ;
Becker, William C. ;
Cerda, Magdalena ;
Crystal, Stephen ;
Gaither, Julie R. ;
Gordon, Adam J. ;
Gordon, Kirsha S. ;
Kerns, Robert D. ;
Martins, Silvia S. ;
Fiellin, David A. ;
Marshall, Brandon D. L. .
ADDICTION, 2016, 111 (11) :2021-2031
[4]   NMDA Receptor Hypofunction in the Prelimbic Cortex Increases Sensitivity to the Rewarding Properties of Opiates via Dopaminergic and Amygdalar Substrates [J].
Bishop, Stephanie F. ;
Lauzon, Nicole M. ;
Bechard, Melanie ;
Gholizadeh, Shervin ;
Laviolette, Steven R. .
CEREBRAL CORTEX, 2011, 21 (01) :68-80
[5]   An Overview of Translationally Informed Treatments for Posttraumatic Stress Disorder: Animal Models of Pavlovian Fear Conditioning to Human Clinical Trials [J].
Bowers, Mallory E. ;
Ressler, Kerry J. .
BIOLOGICAL PSYCHIATRY, 2015, 78 (05) :E15-E27
[6]   Stress reinstates nicotine seeking but not sucrose solution seeking in rats [J].
Buczek, Y ;
Lê, AD ;
Wang, A ;
Stewart, J ;
Shaham, Y .
PSYCHOPHARMACOLOGY, 1999, 144 (02) :183-188
[7]   Effect of antipsychotic drugs and selective dopaminergic antagonists on dopamine-induced facilitatory activity in prelimbic cortical pyramidal neurons.: An in vitro study [J].
Ceci, A ;
Brambilla, A ;
Duranti, P ;
Grauert, M ;
Grippa, N ;
Borsini, F .
NEUROSCIENCE, 1999, 93 (01) :107-115
[8]   PTSD and cognitive symptoms relate to inhibition-related prefrontal activation and functional connectivity [J].
Clausen, Ashley N. ;
Francisco, Alex J. ;
Thelen, Joan ;
Bruce, Jared ;
Martin, Laura E. ;
McDowd, Joan ;
Simmons, W. Kyle ;
Aupperle, Robin L. .
DEPRESSION AND ANXIETY, 2017, 34 (05) :427-436
[9]   The effects of AMPA receptor blockade in the prelimbic cortex on systemic and ventral tegmental area opiate reward sensitivity [J].
De Jaeger, Xavier ;
Bishop, Stephanie F. ;
Ahmad, Tasha ;
Lyons, Danika ;
Ng, Garye Ami ;
Laviolette, Steven R. .
PSYCHOPHARMACOLOGY, 2013, 225 (03) :687-695
[10]   Anxiety sensitivity and the situational antecedents to drug and alcohol use: An evaluation of anxiety patients with substance use disorders [J].
DeHaas, RAB ;
Calamari, JE ;
Bair, JP .
COGNITIVE THERAPY AND RESEARCH, 2002, 26 (03) :335-353