The multifaceted circulating endothelial cell in cancer: towards marker and target identification

被引：468
作者：
Bertolini, Francesco [1 ]
Shaked, Yuval
Mancuso, Patrizia
Kerbel, Robert S.
机构：
[1] European Inst Oncol, Div Hematol Oncol, Dept Med, I-20141 Milan, Italy
[2] Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Med Biophys, Toronto, ON M4N 3M5, Canada
来源：
NATURE REVIEWS CANCER | 2006年 / 6卷 / 11期
关键词：
D O I：
10.1039/nrc1971
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Increases in the number of circulating endothelial cells (CECs) and progenitors (CEPs) have been reported in various pathological conditions including cancer. Preclinical studies have shown that CEC and CEP kinetics correlate well with several standard laboratory angiogenesis assays, which cannot be used in humans. At the clinical level, evidence is emerging that CEC kinetics and viability might correlate with clinical outcomes in cancer patients who undergo anti- angiogenic treatment. Therefore, CEC and CEP measurement has potential as a surrogate marker for monitoring anti-angiogenic treatment and drug activity, and could help to determine the optimal biological dose of anti-angiogenic drugs, which are being used with increasing frequency in medical oncology.
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收藏
页码：833 / 845
页数：11
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