Aflatoxins inhibit prolactin secretion by rat pituitary cells in culture

被引：6

作者：

Abdel-Haq, H ^{[1
]}

Giacomelli, S ^{[1
]}

Palmery, M ^{[1
]}

Leone, MG ^{[1
]}

Saso, L ^{[1
]}

Silvestrini, B ^{[1
]}

机构：

[1] Univ Rome La Sapienza, Dept Pharmacol & Nat Subst & Gen Physiol, I-00185 Rome, Italy

来源：

DRUG AND CHEMICAL TOXICOLOGY | 2000年 / 23卷 / 02期

关键词：

D O I：

10.1081/DCT-100100123

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Acute effects of aflatoxins (AF), and in particular hormonal actions, have not been examined as much as chronic toxicity. Thus, we studied the effects of specific AF on prolactin (PRL) secretion by rat pituitary cells in culture. AFB(1) and AFQ(1) (1 x 10(-4) M) reduced the stimulating effect of dimethyl sulfoxide on PRL secretion by cultured rat pituitary cells. The mechanism responsible for this action is still unknown, but it did not seem to be a non specific toxic effect, because AFB(1), at the same concentration, did not significantly alter cell viability, as indicated by the Trypan blue dye-exclusion test.

引用

页码：381 / 386

页数：6

共 20 条

[1]

[Anonymous], 1994, TOXICOLOGY AFLATOXIN

[2] EVIDENCE THAT STIMULATION OF GROWTH-HORMONE RELEASE BY EPINEPHRINE AND VASOACTIVE-INTESTINAL-PEPTIDE IS BASED ON CELL-TO-CELL COMMUNICATION IN THE PITUITARY [J].

BAES, M ;

DENEF, C .

ENDOCRINOLOGY, 1987, 120 (01) :280-290

[3] DOPAMINE - A PROLACTIN-INHIBITING HORMONE [J].

BENJONATHAN, N .

ENDOCRINE REVIEWS, 1985, 6 (04) :564-589

[4]

BUCHI GH, 1974, RES COMMUN CHEM PATH, V8, P585

[5]

Busby WF, 1984, ACS MONOGR SER, V182, P945

[6] THE RESPONSE OF THE ANTERIOR-PITUITARY AND TESTES TO SYNTHETIC LUTEINIZING-HORMONE-RELEASING HORMONE (LHRH) AND THE EFFECT OF CASTRATION ON PITUITARY REPONSIVENESS IN THE MATURING CHICKEN FED AFLATOXIN [J].

CLARKE, RN ;

OTTINGER, MA .

BIOLOGY OF REPRODUCTION, 1987, 37 (03) :556-563

[7]

CoulombeJr R. A., 1994, TOXICOLOGY AFLATOXIN, P89

[8] DISSOCIATION OF DOPAMINE FROM ITS RECEPTOR AS A SIGNAL IN THE PLEIOTROPIC HYPOTHALAMIC REGULATION OF PROLACTIN SECRETION [J].

DELAESCALERA, GM ;

WEINER, RI .

ENDOCRINE REVIEWS, 1992, 13 (02) :241-255

[9] MECHANISM OF AFLATOXIN CARCINOGENESIS [J].

EATON, DL ;

GALLAGHER, EP .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1994, 34 :135-172

[10]

EDDS GT, 1973, J AM VET MED ASSOC, V162, P304

← 1 2 →