Reactive oxygen species: The signal regulator of B cell

被引：33
|
作者：
Zhang, Hushan [1 ]
Wang, Luman [1 ,2 ]
Chu, Yiwei [1 ,2 ]
机构：
[1] Fudan Univ, Inst Biomed Sci, Sch Basic Med Sci, Dept Immunol, Shanghai 200032, Peoples R China
[2] Fudan Univ, Biotherapy Res Ctr, Shanghai 200032, Peoples R China
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 2019年 / 142卷
基金：
中国国家自然科学基金;
关键词：
Reactive oxygen species; B cell; Signaling pathway; NADPH OXIDASE; T-CELL; OXIDATIVE STRESS; SUPEROXIDE-DISMUTASE; REVERSIBLE OXIDATION; N-ACETYLCYSTEINE; CROSS-LINKING; NOX FAMILY; LYMPHOCYTES; RECEPTOR;
D O I：
10.1016/j.freeradbiomed.2019.06.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Reactive oxygen species (ROS) are indispensable for determining the fate of immune cells in both physiological and pathogenic environments, thus stimulating the interest of immunologists and clinicians. B cells are essential in maintaining immune homeostasis, and studies have indicated that ROS affect the maturation, activation and differentiation of B cells by controlling the signaling molecules in various molecular pathways. In the present review, we aimed to summarize the biological properties of ROS and the mechanisms by which ROS regulate B cell signaling pathways. We propose that ROS and their mediated signal transduction can be a new approach for manipulating B cell immune functions.
引用
收藏
页码：16 / 22
页数：7
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