Nanoceria as a possible agent for the management of COVID-19

被引:59
作者
Allawadhi, Prince [1 ]
Khurana, Amit [2 ,3 ]
Allwadhi, Sachin [4 ]
Joshi, Kamaldeep [4 ]
Packirisamy, Gopinath [1 ,5 ]
Bharani, Kala Kumar [2 ]
机构
[1] Indian Inst Technol IIT, Dept Biotechnol, Roorkee 247667, Uttarakhand, India
[2] PVNRTVU, Dept Vet Pharmacol & Toxicol, Coll Vet Sci CVSc, Hyderabad 500030, Telangana, India
[3] Indian Inst Technol IIT, Ctr Biomed Engn CBME, Delhi 110016, India
[4] Maharshi Dayanand Univ MDU, Univ Inst Engn & Technol UIET, Dept Comp Sci & Engn, Rohtak 124001, Haryana, India
[5] Indian Inst Technol IIT, Ctr Nanotechnol, Nanobiotechnol Lab, Roorkee 247667, Uttarakhand, India
关键词
COVID-19; Nanoceria; Cytokine storm; Lung fibrosis; SARS-CoV-2; CERIUM OXIDE NANOPARTICLES; INDUCED OXIDATIVE STRESS; TGF-BETA; PROTECT; PATHOGENESIS; INHIBITION; SEPSIS; MODEL;
D O I
10.1016/j.nantod.2020.100982
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The COVID-19 pandemic has emerged as an unprecedented global healthcare emergency and has devastated the global economy. The SARS-CoV-2 virus replicates in the host cells and is seemingly much more virulent compared to other flu viruses, as well as the SARS-CoV-1. The respiratory complications of the disease include acute respiratory distress syndrome (ARDS), cytokine storm, systemic inflammation, and pulmonary fibrosis. Nanoceria (NC) is a versatile rare earth nanoparticle with remarkable catalase and superoxide dismutase mimetic redox regenerative properties. Interestingly, NC possesses promising anti-inflammatory, antioxidant and anti-fibrotic properties, making it an attractive tool to fight against the SARS-CoV-2 as well as the associated systemic complications. Until now, there is no clinically approved vaccine or drug for the treatment of COVID-19, and the conquest to find a novel therapy for this global havoc is being undertaken at a warlike pace. Herein, based on preclinical evidence, we hypothesize that NC owing to its unique pharmacological properties, might be an attractive preclinical candidate to win the battle over COVID-19. Further, it may be used as a prevention or treatment strategy in combination with other drugs. (C) 2020 Elsevier Ltd. All rights reserved.
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页数:6
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