Synthesis of a novel tetrahydroisoquinolino[2,1-c][1,4]benzodiazepine ring system with DNA recognition potential

被引：9

作者：

Kothakonda, KK

Bose, DS

机构：

[1] Univ Montreal, Dept Chem, Montreal, PQ H3C 3J7, Canada

[2] Indian Inst Chem Technol, Fine Chem Lab, Hyderabad 500007, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 17期

关键词：

molecular recognition; DNA binding; sequence-selective; PBDs; tetrahydroisoquinolino[2,1-c][1,4]benzodiazepine;

D O I：

10.1016/j.bmcl.2004.07.001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We report the first stereospecific synthesis and reactivity of a novel tetrahydroisoquinolino[2,1-c][1,4]benzodiazepine ring system with DNA recognition potential. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：4371 / 4373

页数：3

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