A Simple Synthesis of 1-Substituted Diethyl Pyrrole-3,4-dicarboxylates

被引：1

作者：

Skrlep, Luka ^{[1
]}

Cercek-Hocevar, Andreja ^{[1
]}

Jakse, Renata ^{[1
]}

Stanovnik, Branko ^{[1
]}

Svete, Jurij ^{[1
]}

机构：

[1] Univ Ljubljana, Fac Chem & Chem Technol, Ljubljana 1000, Slovenia

来源：

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES | 2009年 / 64卷 / 06期

关键词：

Pyrroles; Enaminones; Amines; Cyclisations; Heterocycles; SOLUTION-PHASE SYNTHESIS; COUPLING-CONSTANTS; TRANSFORMATIONS; HETEROCYCLES; DERIVATIVES; PYRROLES; ALKYL; ENAMINONES; EFFICIENT; ACID;

D O I：

10.1515/znb-2009-0614

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of 1-substituted diethyl 1H-pyrrole-3,4-dicarboxylates 4a-o were prepared in 14-93% yield by acid-catalysed treatment of diethyl 2,3-bis[(E,E)-(dimethylamino)-methylidene]succinate (2) with various aliphatic and (hetero)aromatic primary amines 3a-o. The configuration of the C=C double bonds in the bis-enaminone 2 was determined by (HNMR)-H-1 and HMBC spectroscopy.

引用

页码：683 / 688

页数：6

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