Tracking early response to immunotherapy

被引：8

作者：

Boland, Genevieve M. ^{[1
]}

Flaherty, Keith T. ^{[2
]}

机构：

[1] Massachusetts Gen Hosp, Dept Surg, Boston, MA 02114 USA

[2] Harvard Med Sch, Dept Med, Boston, MA 02115 USA

来源：

NATURE CANCER | 2020年 / 1卷 / 02期

关键词：

BLOCKADE;

D O I：

10.1038/s43018-020-0032-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Identifying indicators of response to immunotherapy is key for treatment decisions. Two studies now report that early changes in T cell repertoires and CD8+ memory effector cytotoxic T cells in peripheral blood correlate with response to immune-checkpoint inhibitors in metastatic melanoma and may serve as actionable biomarkers of immune activation.

引用

页码：160 / 162

页数：3

共 9 条

[1] Peripheral CD8+ T cell characteristics associated with durable responses to immune checkpoint blockade in patients with metastatic melanoma [J].

Fairfax, Benjamin P. ;

Taylor, Chelsea A. ;

Watson, Robert A. ;

Nassiri, Isar ;

Danielli, Sara ;

Fang, Hai ;

Mahe, Elise A. ;

Cooper, Rosalin ;

Woodcock, Victoria ;

Traill, Zoe ;

Al-Mossawi, M. Hussein ;

Knight, Julian C. ;

Klenerman, Paul ;

Payne, Miranda ;

Middleton, Mark R. .

NATURE MEDICINE, 2020, 26 (02) :193-+

[2] Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients [J].

Gros, Alena ;

Parkhurst, Maria R. ;

Tran, Eric ;

Pasetto, Anna ;

Robbins, Paul F. ;

Ilyas, Sadia ;

Prickett, Todd D. ;

Gartner, Jared J. ;

Crystal, Jessica S. ;

Roberts, Ilana M. ;

Trebska-McGowan, Kasia ;

Wunderlich, John R. ;

Yang, James C. ;

Rosenberg, Steven A. .

NATURE MEDICINE, 2016, 22 (04) :433-+

[3] A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma [J].

Huang, Alexander C. ;

Orlowski, Robert J. ;

Xu, Xiaowei ;

Mick, Rosemarie ;

George, Sangeeth M. ;

Yan, Patrick K. ;

Manne, Sasikanth ;

Kraya, Adam A. ;

Wubbenhorst, Bradley ;

Dorfman, Liza ;

D'Andrea, Kurt ;

Wenz, Brandon M. ;

Liu, Shujing ;

Chilukuri, Lakshmi ;

Kozlov, Andrew ;

Carberry, Mary ;

Giles, Lydia ;

Kier, Melanie W. ;

Quagliarello, Felix ;

McGettigan, Suzanne ;

Kreider, Kristin ;

Annamalai, Lakshmanan ;

Zhao, Qing ;

Mogg, Robin ;

Xu, Wei ;

Blumenschein, Wendy M. ;

Yearley, Jennifer H. ;

Linette, Gerald P. ;

Amaravadi, Ravi K. ;

Schuchter, Lynn M. ;

Herati, Ramin S. ;

Bengsch, Bertram ;

Nathanson, Katherine L. ;

Farwell, Michael D. ;

Karakousis, Giorgos C. ;

Wherry, E. John ;

Mitchell, Tara C. .

NATURE MEDICINE, 2019, 25 (03) :454-+

[4] T-cell invigoration to tumour burden ratio associated with anti-PD-1 response [J].

Huang, Alexander C. ;

Postow, Michael A. ;

Orlowski, Robert J. ;

Mick, Rosemarie ;

Bengsch, Bertram ;

Manne, Sasikanth ;

Xu, Wei ;

Harmon, Shannon ;

Giles, Josephine R. ;

Wenz, Brandon ;

Adamow, Matthew ;

Kuk, Deborah ;

Panageas, Katherine S. ;

Carrera, Cristina ;

Wong, Phillip ;

Quagliarello, Felix ;

Wubbenhorst, Bradley ;

D'Andrea, Kurt ;

Pauken, Kristen E. ;

Herati, Ramin S. ;

Staupe, Ryan P. ;

Schenkel, Jason M. ;

McGettigan, Suzanne ;

Kothari, Shawn ;

George, Sangeeth M. ;

Vonderheide, Robert H. ;

Amaravadi, Ravi K. ;

Karakousis, Giorgos C. . ;

Schuchter, Lynn M. ;

Xu, Xiaowei ;

Nathanson, Katherine L. ;

Wolchok, Jedd D. ;

Gangadhar, Tara C. ;

Wherry, E. John .

NATURE, 2017, 545 (7652) :60-+

[5] Mechanisms of resistance to immune checkpoint inhibitors [J].

Jenkins, Russell W. ;

Barbie, David A. ;

Flaherty, Keith T. .

BRITISH JOURNAL OF CANCER, 2018, 118 (01) :9-16

[6] High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy [J].

Krieg, Carsten ;

Nowicka, Malgorzata ;

Guglietta, Silvia ;

Schindler, Sabrina ;

Hartmann, Felix J. ;

Weber, Lukas M. ;

Dummer, Reinhard ;

Robinson, Mark D. ;

Levesque, Mitchell P. ;

Becher, Burkhard .

NATURE MEDICINE, 2018, 24 (02) :144-+

[7] Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab [J].

Riaz, Nadeem ;

Havel, Jonathan J. ;

Makarov, Vladimir ;

Desrichard, Alexis ;

Urba, Walter J. ;

Sims, Jennifer S. ;

Hodi, F. Stephen ;

Martin-Algarra, Salvador ;

Mandal, Rajarsi ;

Sharfman, William H. ;

Bhatia, Shailender ;

Hwu, Wen-Jen ;

Gajewski, Thomas F. ;

Slingluff, Craig L., Jr. ;

Chowell, Diego ;

Kendall, Sviatoslav M. ;

Chang, Han ;

Shah, Rachna ;

Kuo, Fengshen ;

Morris, Luc G. T. ;

Sidhom, John-William ;

Schneck, Jonathan P. ;

Horak, Christine E. ;

Weinhold, Nils ;

Chan, Timothy A. .

CELL, 2017, 171 (04) :934-+

[8] PD-1 Blockade Expands Intratumoral Memory T Cells [J].

Ribas, Antoni ;

Shin, Daniel Sanghoon ;

Zaretsky, Jesse ;

Frederiksen, Juliet ;

Cornish, Andrew ;

Avramis, Earl ;

Seja, Elizabeth ;

Kivork, Christine ;

Siebert, Janet ;

Kaplan-Lefko, Paula ;

Wang, Xiaoyan ;

Chmielowski, Bartosz ;

Glaspy, John A. ;

Tumeh, Paul C. ;

Chodon, Thinle ;

Pe'er, Dana ;

Comin-Anduix, Begona .

CANCER IMMUNOLOGY RESEARCH, 2016, 4 (03) :194-203

[9] Immune awakening revealed by peripheral T cell dynamics after one cycle of immunotherapy [J].

Valpione, Sara ;

Galvani, Elena ;

Tweedy, Joshua ;

Mundra, Piyushkumar A. ;

Banyard, Antonia ;

Middlehurst, Philippa ;

Barry, Jeff ;

Mills, Sarah ;

Salih, Zena ;

Weightman, John ;

Gupta, Avinash ;

Gremel, Gabriela ;

Baenke, Franziska ;

Dhomen, Nathalie ;

Lorigan, Paul C. ;

Marais, Richard .

NATURE CANCER, 2020, 1 (02) :210-+

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