Branched DNA technology in molecular diagnostics

被引：67

作者：

Tsongalis, Gregory J. ^{[1
]}

机构：

[1] Dartmouth Hitchcock Med Ctr, Mol Pathol Lab, Dartmouth Med Sch, Dept Pathol, Lebanon, NH 03756 USA

来源：

AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2006年 / 126卷 / 03期

关键词：

microbiology; virology; molecular diagnostics;

D O I：

10.1039/90BU6KDXANFLN4RJ

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Viral quantification or viral load testing has become part of the routine management of patients infected with HIV-1 or hepatitis C virus (HCV). There are currently several molecular technologies that are available for use in the clinical laboratory setting. Of these, only the branched DNA (bDNA) assays are FDA-approved for HIV-1 and HCV viral load testing. This signal amplification technology is built on a series of hybridization reactions that are highly amenable to full automation and thus lessen the amount of labor required to perform this type of analysis. This article provides a historical perspective of bDNA and its clinical applications.

引用

页码：448 / 453

页数：6

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