COVID-19 has been sweeping the world for nearly two years. As the virus continues to mutate, epidemic prevention and control has become a long and experienced war. In the face of the sudden spread of virus strains, how to quickly and effectively formulate prevention and control plans is the most important to ensure the safety and social stability of cities. This paper is based on the characteristics of the persistence of the epidemic and the rapid transmission of the mutant strain, as well as the database of epidemic prevention and control plans formed by the existing prevention and control. Then, epidemic prevention experts select effective alternatives from the program database and rank their preferences through the preliminary analysis of the local epidemic situation. The process of the integration scheme is to minimize the differences to maximize the needs of the local epidemic, and then obtain the consensus ranking of the scheme and determine the final prevention and control scheme. The proposed method of this paper, on the one hand, can optimize the opinions of the epidemic prevention expert group and form a consensus decision. On the other hand, it can save time and carry out the work effectively, which is of certain practical significance to the prevention and control work of local outbreaks.