Tocilizumab and Remdesivir in a Pregnant Patient With Coronavirus Disease 2019 (COVID-19)

被引：38

作者：

Naqvi, Mariam

Zakowski, Phillip

Glucksman, Lindsey

Smithson, Sarah

Burwick, Richard M.

机构：

[1] Cedars Sinai Med Ctr, Div Maternal Fetal Med, Dept Obstet & Gynecol, Div Infect Dis,Dept Internal Med, Los Angeles, CA 90048 USA

[2] Cedars Sinai Med Ctr, Dept Internal Med, Los Angeles, CA 90048 USA

来源：

OBSTETRICS AND GYNECOLOGY | 2020年 / 136卷 / 05期

关键词：

D O I：

10.1097/AOG.0000000000004050

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

BACKGROUND: There are limited data regarding treatment options for pregnant women with severe coronavirus disease 2019 (COVID-19). CASE: A 35-year-old primigravid patient at 22 weeks of gestation presented with 7 days of fever, cough, anosmia, and dyspnea. Nasopharyngeal swab was positive for the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and a chest X-ray demonstrated bilateral patchy infiltrates. Laboratory evaluation was notable for marked elevation of interleukin-6 and C-reactive protein concentrations. On hospital day 3, owing to increased dyspnea and oxygen requirement, the patient was treated with tocilizumab followed by 5 days of remdesivir. She responded well, recovered to room air, and was discharged home after a 9-day hospitalization. CONCLUSION: Tocilizumab and remdesivir may be effective for treatment of severe COVID-19 in pregnancy, but additional data are needed to guide risk-benefit considerations.

引用

页码：1025 / 1029

页数：5

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