Synthesis of functionalized nitrogen heterocycles from β- and γ-amino acids by radical decarboxylation

被引：17
|
作者：
Boto, A
Hernández, R
de León, Y
Murguía, JR
Rodríguez-Afonso, A
机构：
[1] CSIC, Inst Prod Nat & Agrobiol, San Cristobal la Laguna 38206, Tenerife, Spain
[2] Hosp Univ Canarias, Unidad Invest, San Cristobal la Laguna 38320, Tenerife, Spain
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 37期
关键词：
radicals; piperidines; arylpiperidines; pyrrolidines; decarboxylation; amino acids; antifungic;
D O I：
10.1016/j.tetlet.2004.07.111
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The radical decarboxylation of beta- and gamma-amino acids on treatment with Phl(OAC)(2)-I-2 is a mild and efficient methodology to synthesize halogenated or oxygenated nitrogen heterocycles. The reaction was applied to the synthesis of bioactive products, such as opioid analogues, iminosugars and new antifungic agents. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6841 / 6845
页数：5
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