A Smart, Photocontrollable Drug Release Nanosystem for Multifunctional Synergistic Cancer Therapy

被引：61
|
作者：
Yi, Yi [1 ,2 ]
Wang, Huijing [1 ,2 ]
Wang, Xuewei [1 ,2 ]
Liu, Qiaoling [1 ,2 ]
Ye, Mao [1 ,2 ]
Tan, Weihong [1 ,2 ,3 ,4 ]
机构：
[1] Hunan Univ, Coll Chem & Chem Engn, Mol Sci & Biomed Lab, Coll Biol,State Key Lab Chemo Biosensing & Chemom, Changsha 410082, Hunan, Peoples R China
[2] Hunan Univ, Collaborat Res Ctr Mol Engn Theranost, Changsha 410082, Hunan, Peoples R China
[3] Univ Florida, Genet Inst, Ctr Res Bio Nano Interface, Dept Chem,Dept Physiol & Funct Genom,Shands Canc, Gainesville, FL 32611 USA
[4] Univ Florida, McKnight Brain Inst, Gainesville, FL 32611 USA
来源：
ACS APPLIED MATERIALS & INTERFACES | 2017年 / 9卷 / 07期
基金：
中国国家自然科学基金;
关键词：
multimodal therapy; drug release; photothermal therapy; photodynamic therapy; gold nanorod; aptamer; NEAR-INFRARED LIGHT; CHEMO-PHOTOTHERMAL THERAPY; GOLD NANORODS; DELIVERY-SYSTEM; THERANOSTIC NANOPLATFORM; PHOTODYNAMIC THERAPY; RECENT PROGRESS; NANOPARTICLES; APTAMER; CHEMOTHERAPY;
D O I：
10.1021/acsami.6b15414
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Multifunctional synergistic therapy holds promise in biomedical studies and clinical practice. However, strategies aimed at easily integrating the components of such multimodal therapies are needed. Therefore, we herein report a smart drug release nanosystem able to perform photodynamic therapy, photothermal therapy and chemotherapy in a photocontrollable manner. Doxorubicin (DOX), a chemotherapy drug, and 5, 10, 15, 20-tetrakis (1-methylpyridinium-4yl) porphyrin (TMPyP4), a photosensitizer, were physically intercalated into a DNA assembly immobilized on gold nanorods. The drugs were efficiently delivered to target cells and released under light irradiation, resulting in a synergism that combined phototherapy and chemotherapy treatment. This smart, photocontrollable drug release nanosystem promises precisely controlled drug release for multifunctional synergistic cancer therapy.
引用
收藏
页码：5847 / 5854
页数：8
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