Synthesis of 1-Difluoroalkylated Isoquinolines via Palladium-Catalyzed Radical Cascade Difluoroalkylation-Cyclization of Vinyl Isocyanides with Bromodifluoroacetic Derivatives

被引：19

作者：

Liu, Yingle ^{[1
]}

Zhang, Ke ^{[2
]}

Jiang, Weidong ^{[1
]}

Yang, Yi ^{[1
]}

Jiang, Yan ^{[1
]}

Liu, Xiaoqiang ^{[1
]}

Xie, Ying ^{[1
]}

Wu, Jincai ^{[1
]}

Cai, Junjie ^{[1
]}

Xu, Xiu-Hua ^{[3
]}

机构：

[1] Sichuan Univ Sci & Engn, Sch Chem & Environm Engn, 180 Xueyuan St, Zigong 643000, Sichuan, Peoples R China

[2] Donghua Univ, Coll Chem Chem Engn & Biotechnol, 2999 North Renmin Rd, Shanghai 201620, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2017年 / 12卷 / 05期

关键词：

difluoroalkylation; gem-difluoromethylene; isoquinolines; palladium; radical reactions; C-H ETHOXYCARBONYLDIFLUOROMETHYLATION; INTERNAL ALKYNES; BOND ACTIVATION; RECENT PROGRESS; BORONIC ACIDS; LIGHT; ALKENES; FLUOROALKYLATION; ACCESS; DIFLUOROACETAMIDATION;

D O I：

10.1002/asia.201601645

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A general method was developed for the synthesis of 1-difluoroalkyl isoquinolines via the palladium-catalyzed radical cascade difluoroalkylation-cyclization of vinyl isocyanides with bromodifluoroacetic derivatives. The difluoroalkylated cyclization products were readily converted to various other valuable gem-difluoro-containing compounds.

引用

页码：568 / 576

页数：9

共 89 条

[1] Palladium-Catalyzed Negishi Cross-Coupling Reaction of Aryl Halides with (Difluoromethyl)zinc Reagent [J].