Anti-inflammatory properties of Type I interferons

被引：72
作者：
Billiau, Alfons [1 ]
机构：
[1] Katholieke Univ Leuven, Rega Inst, BE-3000 Louvain, Belgium
来源：
ANTIVIRAL RESEARCH | 2006年 / 71卷 / 2-3期
关键词：
interferon; inflammation;
D O I：
10.1016/j.antiviral.2006.03.006
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The notion that Type I interferons (interferon-alpha and -beta) possess anti-inflammatory potential is supported by data from clinical application in multiple sclerosis, by studies on cultured immune-competent cells and by investigation of experimental diseases in whole animals. These observations deserve the attention of virologists for their potential role in the pathogenesis and clinical management of virus infections. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：108 / 116
页数：9
相关论文
共 87 条
[41]   Monocyte-derived dendritic cells express and secrete matrix-degrading metalloproteinases and their inhibitors and are imbalanced in multiple sclerosis [J].
Kouwenhoven, M ;
Özenci, V ;
Tjernlund, A ;
Pashenkov, M ;
Homman, M ;
Press, R ;
Link, H .
JOURNAL OF NEUROIMMUNOLOGY, 2002, 126 (1-2) :161-171
[42]   Peginterferon alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B [J].
Lau, GKK ;
Piratvisuth, T ;
Luo, KX ;
Marcellin, P ;
Thongsawat, S ;
Cooksley, G ;
Gane, E ;
Fried, MW ;
Chow, WC ;
Paik, SW ;
Chang, WY ;
Berg, T ;
Flisiak, R ;
McCloud, P ;
Pluck, N .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (26) :2682-2695
[43]   Chemokine up-regulation in SARS-coronavirus-infected, monocyte-derived human dendritic cells [J].
Law, HKW ;
Cheung, CY ;
Ng, HY ;
Sia, SF ;
Chan, YO ;
Luk, W ;
Nicholls, JM ;
Peiris, JSM ;
Lau, YL .
BLOOD, 2005, 106 (07) :2366-2374
[44]   Intrathecal synthesis of matrix metalloproteinase-9 in patients with multiple sclerosis: implication for pathogenesis [J].
Liuzzi, GM ;
Trojano, M ;
Fanelli, M ;
Avolio, C ;
Fasano, A ;
Livrea, P ;
Riccio, P .
MULTIPLE SCLEROSIS, 2002, 8 (03) :222-228
[45]   Microglial phagocytosis of apoptotic inflammatory T cells leads to down-regulation of microglial immune activation [J].
Magnus, T ;
Chan, A ;
Grauer, O ;
Toyka, KV ;
Gold, R .
JOURNAL OF IMMUNOLOGY, 2001, 167 (09) :5004-5010
[46]  
Matthys P, 2000, J LEUKOCYTE BIOL, V68, P447
[47]   Type I interferons produced by dendritic cells promote their phenotypic and functional activation [J].
Montoya, M ;
Schiavoni, G ;
Mattei, F ;
Gresser, I ;
Belardelli, F ;
Borrow, P ;
Tough, DF .
BLOOD, 2002, 99 (09) :3263-3271
[48]  
NEDWIN GE, 1985, J IMMUNOL, V135, P2492
[49]   Gelatinase B/matrix metalloproteinase-9 cleaves interferon-β and is a target for immunotherapy [J].
Nelissen, I ;
Martens, E ;
Van Den Steen, PE ;
Proost, P ;
Ronsse, I ;
Opdenakker, G .
BRAIN, 2003, 126 :1371-1381
[50]  
Nelissen I, 2002, J LEUKOCYTE BIOL, V71, P89
123456789