A convenient method for the conversion of a carboxy group into a 4,6-dimethoxy-1,3,5-triazine group:: Application to N-benzylpyroglutamic acids

被引：15

作者：

Oudir, Souhila

Rigo, Benoit

Henichart, Jean-Pierre

Gautret, Philippe

机构：

[1] Ecole Hautes Etud Ingenieur, F-59046 Lille, France

[2] Univ Lille 2, Inst Chim Pharmaceut Albert Lespagnol, Grp Rech Inhibit Proliferat Cellulaire, EA 2692, F-59006 Lille, France

来源：

SYNTHESIS-STUTTGART | 2006年 / 17期

关键词：

pyroglutamic derivatives; lactams; imidodicarbonimidate zinc salt; heterocycles; triazines;

D O I：

10.1055/s-2006-942519

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of an activated form of carboxylic acids with a stoichiometric amount of zinc dimethyl imidodicarbonimidate (in CH2Cl2-pyridine with molecular sieves), led to 4,6-dimethoxy-1,3,5-triazines in high yields. This method has been applied to N-benzylpyroglutamic acids, in the preparation of potential antifungal products.

引用

页码：2845 / 2848

页数：4

共 18 条

[1] STUDIES ON PYRROLIDINONES - SYNTHESIS OF 2-(5-OXO-2-PYRROLIDINYL)-1,3,4-OXADIAZOLES AND 2-(5-OXO-2-PYRROLIDINYL)BENZIMIDAZOLES [J].