One-pot synthesis of magnesium nanoparticles embedded in a chitosan microparticle matrix: a highly biocompatible tool for in vivo cancer treatment

被引：16

作者：

Martin, Robert. C. ^{[1
]}

Locatelli, Erica ^{[2
]}

Li, Yan ^{[1
]}

Matteini, Paolo ^{[3
]}

Monaco, Ilaria ^{[2
]}

Cui, Guozhen ^{[1
]}

Li, Suping ^{[1
]}

Banchelli, Martina ^{[3
]}

Pini, Roberto ^{[3
]}

Franchini, Mauro Comes ^{[2
]}

机构：

[1] Univ Louisville, Dept Surg, Div Surg Oncol, Louisville, KY 40202 USA

[2] Univ Bologna, Dept Ind Chem Toso MOntanari, I-40136 Bologna, Italy

[3] Natl Res Council Italy, Inst Appl Phys Nello Carrara, I-50019 Sesto Fiorentino, Italy

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2016年 / 4卷 / 02期

关键词：

GOLD NANOPARTICLES; THERAPY; RELEASE;

D O I：

10.1039/c5tb02499d

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

A novel highly biocompatible nanosystem made up of a chitosan matrix and filled with magnesium nanoparticles was synthesized using a simple and one-pot strategy, and tested as a promising, well-tolerated tool for photothermal therapy. Moreover, in vivo a proof of concept on hepatocarcinoma-bearing mice is presented.

引用

页码：207 / 211

页数：5

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