Integration of positive and negative growth signals during ras pathway activation in vivo

被引：87
作者：
Frame, S
Balmain, A
机构：
[1] Univ Dundee, Dept Biochem, Div Signal Transduct Therapy, Dundee DD1 5EH, Scotland
[2] Univ Calif San Francisco, Ctr Canc, San Francisco, CA 94115 USA
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2000年 / 10卷 / 01期
关键词：
D O I：
10.1016/S0959-437X(99)00052-0
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Expression of RAS proteins can have either positive or negative effects on cell growth, differentiation and death. New technologies are being developed for the generation of animal models to address the questions of where, when and how much Ras is expressed during tumorigenesis, and how these disparate signals are integrated during multistage carcinogenesis.
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页码：106 / 113
页数：8
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