Chemotherapy and cognition: comprehensive review on doxorubicin-induced chemobrain

被引：68
作者：
El-Agamy, Sara Emad [1 ]
Abdel-Aziz, Amal Kamal [1 ]
Esmat, Ahmed [1 ]
Azab, Samar S. [1 ]
机构：
[1] Ain Shams Univ, Fac Pharm, Dept Pharmacol & Toxicol, Cairo 11566, Egypt
来源：
CANCER CHEMOTHERAPY AND PHARMACOLOGY | 2019年 / 84卷 / 01期
关键词：
Chemobrain; Doxorubicin; Hippocampus; Memory; Neuropsychological tests; TUMOR-NECROSIS-FACTOR; PEGYLATED LIPOSOMAL DOXORUBICIN; ADULT HIPPOCAMPAL NEUROGENESIS; BREAST-CANCER SURVIVORS; CENTRAL-NERVOUS-SYSTEM; ANXIETY-LIKE BEHAVIOR; OXIDATIVE STRESS; ADJUVANT CHEMOTHERAPY; FACTOR-ALPHA; IN-VIVO;
D O I：
10.1007/s00280-019-03827-0
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Chemobrain refers to a common sequela experienced by a substantial subset of cancer patients exposed to chemotherapeutic treatment, a phenomenon that dramatically deteriorates the survivors' quality of life and prevents them from restoring their pre-cancer life. This review is intended to address the current knowledge regarding the mechanisms underlying the pathophysiology of the chemobrain phenomenon, with special focus on the antineoplastic agent 'doxorubicin'', which has been shown to be implicated in strenuous central neurotoxicity despite beingalmost entirelyperipherally confined. Moreover, the assessment of the post-chemotherapy cognitive impairment in both human and animal subjects, and the potential pharmacotherapy and behavioral intervention strategies are reviewed.
引用
收藏
页码：1 / 14
页数：14
相关论文
共 122 条
  • [1] The relationship of APOE genotype to neuropsychological performance in long-term cancer survivors treated with standard dose chemotherapy
    Ahles, TA
    Saykin, AJ
    Noll, WW
    Furstenberg, CT
    Guerin, S
    Cole, B
    Mott, LA
    [J]. PSYCHO-ONCOLOGY, 2003, 12 (06) : 612 - 619
  • [2] Cognitive function in breast cancer patients prior to adjuvant treatment
    Ahles, Tim A.
    Saykin, Andrew J.
    McDonald, Brenna C.
    Furstenberg, Charlotte T.
    Cole, Bernard F.
    Hanscom, Brett S.
    Mulrooney, Tamsin J.
    Schwartz, Gary N.
    Kaufman, Peter A.
    [J]. BREAST CANCER RESEARCH AND TREATMENT, 2008, 110 (01) : 143 - 152
  • [3] Ahles Tim A, 2002, Clin Breast Cancer, V3 Suppl 3, pS84, DOI 10.3816/CBC.2002.s.018
  • [4] Cancer- and Cancer Treatment-Associated Cognitive Change: An Update on the State of the Science
    Ahles, Tim A.
    Root, James C.
    Ryan, Elizabeth L.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (30) : 3675 - 3686
  • [5] 2-Mercaptoethane sulfonate prevents doxorubicin-induced plasma protein oxidation and TNF-α release: Implications for the reactive oxygen species-mediated mechanisms of chemobrain
    Aluise, Christopher D.
    Miriyala, Sumitra
    Noel, Teresa
    Sultana, Rukhsana
    Jungsuwadee, Paiboon
    Taylor, Tamara J.
    Cai, Jian
    Pierce, William M.
    Vore, Mary
    Moscow, Jeffrey A.
    St Clair, Daret K.
    Butterfield, Allan
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2011, 50 (11) : 1630 - 1638
  • [6] Aluise CD, 2010, ADV EXP MED BIOL, V678, P147
  • [7] [Anonymous], 2008, MEDICINE
  • [8] [Anonymous], AM SOC CLIN ONCOL ED
  • [9] In vivo neuroimaging and behavioral correlates in a rat model of chemotherapy-induced cognitive dysfunction
    Barry, Robert L.
    Byun, Nellie E.
    Tantawy, M. Noor
    Mackey, Chase A.
    Wilson, George H., III
    Stark, Adam J.
    Flom, Michael P.
    Gee, Laura C.
    Quarles, C. Chad
    [J]. BRAIN IMAGING AND BEHAVIOR, 2018, 12 (01) : 87 - 95
  • [10] Tumour necrosis factor - alpha mediated mechanisms of cognitive dysfunction
    Baune, Bernhard T.
    Camara, Marie-Lou
    Eyre, Harris
    Jawahar, Catharine
    Anscomb, Helen
    Koerner, Heinrich
    [J]. TRANSLATIONAL NEUROSCIENCE, 2012, 3 (03) : 263 - 277
12345678910