Identification of MPL W515L/K Mutations in Patients with Primary Myelofibrosis and Essential Thrombocythaemia by Allele-Specific Polymerase Chain Reaction

被引:5
作者
Daly, Sarah [1 ]
Conneally, Eibhlin [1 ]
Langabeer, Stephen E. [1 ]
机构
[1] St James Hosp, Cent Pathol Lab, Dept Haematol, Dublin 8, Ireland
关键词
MYELOPROLIFERATIVE DISORDERS; JAK2;
D O I
10.1159/000224333
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:221 / 222
页数:2
相关论文
共 8 条
  • [1] Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
    Baxter, EJ
    Scott, LM
    Campbell, PJ
    East, C
    Fourouclas, N
    Swanton, S
    Vassiliou, GS
    Bench, AJ
    Boyd, EM
    Curtin, N
    Scott, MA
    Erber, WN
    Green, AR
    [J]. LANCET, 2005, 365 (9464) : 1054 - 1061
  • [2] MPL mutations in myeloproliferative disorders:: analysis of the PT-1 cohort
    Beer, Philip A.
    Campbell, Peter J.
    Scott, Linda M.
    Bench, Anthony J.
    Erber, Wendy N.
    Bareford, David
    Wilkins, Bridget S.
    Reilly, John T.
    Hasselbalch, Hans C.
    Bowman, Richard
    Wheatley, Keith
    Buck, Georgina
    Harrison, Claire N.
    Green, Anthony R.
    [J]. BLOOD, 2008, 112 (01) : 141 - 149
  • [3] Anaemia characterises patients with myelofibrosis harbouring MplW515L/K mutation
    Guglielmelli, Paola
    Pancrazzi, Alessandro
    Bergamaschi, Gaetano
    Rosti, Vittorio
    Villani, Laura
    Antonioli, Elisabetta
    Bosi, Alberto
    Barosi, Giovanni
    Vannucchi, Alessandro M.
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 2007, 137 (03) : 244 - 247
  • [4] Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders
    Levine, Ross L.
    Pardanani, Animesh
    Tefferi, Ayalew
    Gilliland, D. Gary
    [J]. NATURE REVIEWS CANCER, 2007, 7 (09) : 673 - 683
  • [5] TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations
    Pardanani, A.
    Hood, J.
    Lasho, T.
    Levine, R. L.
    Martin, M. B.
    Noronha, G.
    Finke, C.
    Mak, C. C.
    Mesa, R.
    Zhu, H.
    Soll, R.
    Gilliland, D. G.
    Tefferi, A.
    [J]. LEUKEMIA, 2007, 21 (08) : 1658 - 1668
  • [6] MPL515 mutations in myeloproliferative and other myeloid disorders:: a study of 1182 patients
    Pardanani, Animesh D.
    Levine, Ross L.
    Lasho, Terra
    Pikman, Yana
    Mesa, Ruben A.
    Wadleigh, Martha
    Steensma, David P.
    Elliott, Michelle A.
    Wolanskyj, Alexandra R.
    Hogan, William J.
    McClure, Rebecca F.
    Litzow, Mark R.
    Gilliland, D. Gary
    Tefferi, Ayalew
    [J]. BLOOD, 2006, 108 (10) : 3472 - 3476
  • [7] MPLW515L is anovel somatic activating mutation in myelofibrosis with myeloid metaplasia
    Pikman, Yana
    Lee, Benjamin H.
    Mercher, Thomas
    McDowell, Elizabeth
    Ebert, Benjamin L.
    Gozo, Maricel
    Cuker, Adam
    Wernig, Gerlinde
    Moore, Sandra
    Galinsky, Ilene
    DeAngelo, Daniel J.
    Clark, Jennifer J.
    Lee, Stephanie J.
    Golub, Todd R.
    Wadleigh, Martha
    Gilliland, D. Gary
    Levine, Ross L.
    [J]. PLOS MEDICINE, 2006, 3 (07): : 1140 - 1151
  • [8] Characteristics and clinical correlates of MPL 515W>L/K mutation in essential thrombocythemia
    Vannucchi, Alessandro M.
    Antonioli, Elisabetta
    Guglielmelli, Paola
    Pancrazzi, Alessandro
    Guerini, Vittoria
    Barosi, Giovanni
    Ruggeri, Marco
    Specchia, Giorgina
    Lo-Coco, Francesco
    Delaini, Federica
    Villani, Laura
    Finotto, Silvia
    Ammatuna, Emanuele
    Alterini, Renato
    Carrai, Valentina
    Capaccioli, Gloria
    Di Lollo, Simonetta
    Liso, Vincenzo
    Rambaldi, Alessandro
    Bosi, Alberto
    Barbui, Tiziano
    [J]. BLOOD, 2008, 112 (03) : 844 - 847