Microwave assisted efficient synthesis of diphenyl substituted pyrazoles using PEG-600 as solvent - A green approach

被引：9

作者：

Ganapathi, M. ^{[1
]}

Jayaseelan, D. ^{[2
]}

Guhanathan, S. ^{[2
]}

机构：

[1] Govt Arts Coll, PG & Res Dept Chem, Tiruvannamalai, Tamil Nadu, India

[2] Muthurangam Govt Arts Coll Autonomous, PG & Res Dept Chem, Vellore, Tamil Nadu, India

来源：

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 2015年 / 121卷

关键词：

Chalcones; Pyrazole; Piperidine; Antimicrobial activity; PEG-600; Microwave irradiation (MWI); DERIVATIVES; CHALCONES; POTENT;

D O I：

10.1016/j.ecoenv.2015.05.002

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

A conventional and microwave assisted efficient synthesis of diphenyl substituted pyrazole using PEG 600 as green solvent has been described. A relatively shorter reaction time with excellent yield of the piperidine mediated protocol has been attracted economically attractive and eco-friendly. All newly synthesized compounds were characterized by standard spectroscopic techniques viz., UV-visible, FT-IR, H-1-NMR and Mass spectra. The anti-microbial activities of compounds have also been tested using Minimum Inhibitory Concentration (MIC) method with two different microorganisms Staphylococcus aureus (MTCC3381) and Escherichia coli (MTCC739). The results of the antimicrobial activity revealed that the diphenyl substituted pyrazole derivatives have nice inhibiting nature against both types of bacteria of present investigation than corresponding chalcones. Since, the work has been focused on green chemical approach towards the synthesis, this protocol may be recommended for eco-friendly applications. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：87 / 92

页数：6

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