CHEK2 1100delC mutation is frequent among Russian breast cancer patients

被引：28

作者：

Chekmariova, Elena V.

Sokolenko, Anna P.

Buslov, Konstantin G.

Iyevleva, Aglaya G.

Ulibina, Yulia M.

Rozanov, Maxim E.

Mitiushkina, Natalia V.

Togo, Alexandr V.

Matsko, Dmitry E.

Voskresenskiy, Dmitry A.

Chagunava, Oleg L.

Devilee, Peter

Cornelisse, Cees

Semiglazov, Vladimir F.

Imyanitov, Evgeny N.

机构：

[1] NN Petrov Inst Oncol, St Petersburg 197758, Russia

[2] Ctr Mammol, St Petersburg, Russia

[3] Leiden Univ, Med Ctr, Leiden, Netherlands

来源：

BREAST CANCER RESEARCH AND TREATMENT | 2006年 / 100卷 / 01期

基金：

俄罗斯基础研究基金会;

关键词：

CHEK2; 1100delC; mutation; breast cancer predisposition; elderly;

D O I：

10.1007/s10549-006-9227-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This study was aimed to assess the role of CHEK2 1100delC mutation in breast cancer (BC) predisposition in Russia. The 1100delC allele was detected in 14/660 (2.1%) unilateral BC cases and in 8/155 (5.2%) patients with the bilateral form of the disease, but only in 1/448 (0.2%) middle-aged control females and in none of 373 elderly tumor-free women. The obtained data point at potentially high clinical relevance of CHEK2 1100delC testing in females of Russian origin and warrant similar case-control studies in ethnically and geographically related regions, especially in Ukraine, Belarus and Baltic countries.

引用

页码：99 / 102

页数：4

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