Crosstalk between the Producers and Immune Targets of IL-9

被引：23
|
作者：
Van Anh Thi [1 ]
Lee, Jie-Oh [1 ]
Lee, Hayyoung [2 ]
Kim, Young Sang [3 ]
机构：
[1] Pohang Univ Sci & Technol POSTECH, Dept Life Sci, Pohang 37673, South Korea
[2] Chungnam Natl Univ, Inst Biotechnol, 99 Daehak Ro, Daejeon 34134, South Korea
[3] Chungnam Natl Univ, Coll Nat Sci, Dept Biochem, 99 Daehak Ro, Daejeon 34134, South Korea
来源：
IMMUNE NETWORK | 2020年 / 20卷 / 06期
基金：
新加坡国家研究基金会;
关键词：
Interleukin-9; Autoimmune diseases; Allergy; Cancer; Adaptive immunity; Innate immunity; ACTIVATED MAST-CELLS; REGULATORY T-CELLS; TH9; CELLS; DENDRITIC CELLS; AUTOIMMUNE INFLAMMATION; T(H)17 CELLS; TC9; TGF-BETA; INTERLEUKIN-9; EXPRESSION;
D O I：
10.4110/in.2020.20.e45
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
IL-9 has been reported to play dual roles in the pathogenesis of autoimmune disorders and cancers. The collaboration of IL-9 with microenvironmental factors including the broader cytokine milieu and other cellular components may provide important keys to explain its conflicting effects in chronic conditions. In this review, we summarize recent findings on the cellular sources of, and immunological responders to IL-9, in order to interpret the role of IL-9 in the regulation of immune responses. This knowledge will provide new perspectives to improve clinical benefits and limit adverse effects of IL-9 when treating pathologic conditions.
引用
收藏
页码：1 / 16
页数：16
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