An integrated linkage-radiation hybrid map of the canine genome

被引：129

作者：

Mellersh, CS

Hitte, C

Richman, M

Vignaux, F

Priat, C

Jouquand, S

Werner, P

André, C

DeRose, S

Patterson, DF

Ostrander, EA

Galibert, F

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98109 USA

[2] Fac Med 2, UPR 41 CNRS, F-35043 Rennes, France

[3] Univ Penn, Sch Vet Med, Med Genet Sect, Philadelphia, PA 19104 USA

[4] Univ Penn, Sch Vet Med, Ctr Comparat Med Genet, Philadelphia, PA 19104 USA

来源：

MAMMALIAN GENOME | 2000年 / 11卷 / 02期

关键词：

D O I：

10.1007/s003350010024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Purebred dogs are a unique resource for dissecting the molecular basis of simple and complex genetic diseases and traits. As a result of strong selection for physical and behavioral characteristics among the 300 established breeds, modem dogs are characterized by high levels of interbreed variation, complemented by significant intrabreed homogeneity. A high-resolution map of the canine genome is necessary to exploit the mapping power of this unusual resource. We describe here the integration of an expanded canine radiation hybrid map, comprised of 600 markers, with the latest linkage map of 341 markers, to generate a map of 724 markers-the: densest map of the canine genome described to date. Through the inclusion of 217 markers on both the linkage and RH maps, the 77 RH groups are reduced to 44 syntenic groups, thus providing comprehensive coverage of most of the canine genome.

引用

页码：120 / 130

页数：11

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