Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid

被引:54
作者
Tomic, Simonida Lj.
Suljovrujic, Edin H.
Filipovic, Jovanka M.
机构
[1] Univ Belgrade, Fac Technol & Met, Belgrade 11000, Serbia
[2] Vinca Inst Nucl Sci, Belgrade, Serbia
关键词
2-hydroxyethyl methacrylate; itaconic acid; poly(alkylene glycol) (meth)acrylates; hydrogels; physicochemical properties; biological evaluation;
D O I
10.1007/s00289-006-0606-3
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Novel poly(Bisomer/HEMA/IA) hydrogels were prepared by radical copolymerization of poly(alkylene glycol) (meth)acrylates, i.e. short chains Bisomers, 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) in a mixture of water/ethanol as solvent. These hydrogels were characterized in terms of swelling in conditions similar to the biological fluids (pH range 2.20-7.40 buffer solutions), compression-strain measurements, thermal properties and morphology. The influence of the type of Bisomer and of the itaconic acid on swelling and mechanical properties, as well as on morphology and thermal behavior of the resulting hydrogels, were investigated. The in vitro study of biocompatibility, carried out with the hydrogels containing different types of Bisomers, showed no evidence of cell toxicity nor any considerable hemolytic activity. All hydrogels showed satisfactory bioadhesive properties, so these materials have potential as drug carriers or biological glue and sealants.
引用
收藏
页码:691 / 702
页数:12
相关论文
共 40 条
[1]  
ALFREY T, 1966, J POLYM SCI C, V12, P249
[2]   Molecular imprinting within hydrogels [J].
Byrne, ME ;
Park, K ;
Peppas, NA .
ADVANCED DRUG DELIVERY REVIEWS, 2002, 54 (01) :149-161
[3]  
Chen J, 1999, J BIOMED MATER RES, V44, P53, DOI 10.1002/(SICI)1097-4636(199901)44:1<53::AID-JBM6>3.0.CO
[4]  
2-W
[5]  
Chen X, 1997, J APPL POLYM SCI, V65, P2257, DOI 10.1002/(SICI)1097-4628(19970912)65:11<2257::AID-APP23>3.0.CO
[6]  
2-Z
[7]  
Choi HK, 1999, J APPL POLYM SCI, V73, P2749, DOI 10.1002/(SICI)1097-4628(19990923)73:13<2749::AID-APP23>3.0.CO
[8]  
2-9
[9]   Application of a combination of neutral red and amido black staining for rapid, reliable cytotoxicity testing of biomaterials [J].
Ciapetti, G ;
Granchi, D ;
Verri, E ;
Savarino, L ;
Cavedagna, D ;
Pizzoferrato, A .
BIOMATERIALS, 1996, 17 (13) :1259-1264
[10]   Manufacture of poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) hydrogel tubes for use as nerve guidance channels [J].
Dalton, PD ;
Flynn, L ;
Shoichet, MS .
BIOMATERIALS, 2002, 23 (18) :3843-3851