The purpose of this pilot in vitro study was to evaluate the temperature increase in the pulp chamber of the teeth, during Er,Cr:YSGG bleaching, as well as to show which teeth are the most susceptible in terms of pulp temperature increase during laser-activated bleaching treatment. Although Er:YAG studies have been published on this subject, it is the first time Er,Cr:YSGG wavelength is tested. Fifteen teeth were tested-3 each of the following-(maxillary central incisors, lateral incisors, canines, premolars and mandibular incisors). The bleaching procedure comprised an Er,Cr:YSGG laser (2780 nm, Waterlase MD, Biolase, USA) and a yellow-coloured bleaching agent with a concentration of 38 % H2O2 (Power whitening, WHITEsmile GmbH, Germany). The tip used was a 6-mm long Z-type glass tip (MZ8) of a 800 mu m diameter. Average output power was set to 1.25 W, pulse duration 700 mu s (S-mode), whilst the pulse repetition rate was 10 Hz. The results showed that the most susceptible teeth in terms of pulp temperature increase were the lateral maxillary incisors and the mandibular incisors. The mean temperature increase on these teeth was 1.06 and 1.00 A degrees C, respectively, on 60 s Er,Cr:YSGG-supported bleaching.