The mechanisms of radioresistance in esophageal squamous cell carcinoma and current strategies in radiosensitivity

被引：72

作者：

Chen, Guang-Zong ^{[1
]}

Zhu, Hong-Cheng ^{[1
]}

Dai, Wang-Shu ^{[1
]}

Zeng, Xiao-Ning ^{[2
]}

Luo, Jin-Hua ^{[3
]}

Sun, Xin-Chen ^{[1
]}

机构：

[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Radiat Oncol, 300 Guanzhou Rd, Nanjing 210029, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Affiliated Hosp 1, Dept Resp Med, Nanjing 210029, Jiangsu, Peoples R China

[3] Nanjing Med Univ, Affiliated Hosp 1, Dept Thorac Surg, 300 Guanzhou Rd, Nanjing 210029, Jiangsu, Peoples R China

来源：

JOURNAL OF THORACIC DISEASE | 2017年 / 9卷 / 03期

关键词：

Esophageal cancer; radioresistance; tumor-associated microenvironment (TAM); targeted therapy; radiosensitive biomarker; CANCER-ASSOCIATED FIBROBLASTS; DNA-DAMAGE RESPONSE; TUMOR MICROENVIRONMENT; NEOADJUVANT CHEMORADIOTHERAPY; TARGETED THERAPIES; STEM-CELLS; GASTROESOPHAGEAL CANCER; ESOPHAGOGASTRIC CANCER; PATHOLOGICAL RESPONSE; BARRETTS-ESOPHAGUS;

D O I：

10.21037/jtd.2017.03.23

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Esophageal cancer is the eighth most common cancer and the sixth leading cause of cancerrelated death worldwide. Surgery is the primary form of treatment, but the survival is poor, especially for patients with locally advanced esophageal cancer. Radiotherapy has been a critical treatment option that may be combined with chemotherapy in patients with unresectable esophageal cancer. However, resistance to chemoradiotherapy might result in treatment failures and cancer relapse. This review will mainly focus on the possible cellular mechanisms and tumor-associated microenvironmental (TAM) factors that result in radioresistance in patients with esophageal cancer. In addition, current strategies to increase radiosensitivity, including targeted therapy and the use of radiosensitive biomarkers in clinical treatment, are discussed in this review.

引用

页码：849 / 859

页数：11

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