DNA cleavage by a novel acyclic copper(II) complex

被引：17
|
作者：
Xu, XM
Yao, JH
Mao, ZW
Yu, KB
Ji, LN [1 ]
机构：
[1] Natl Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Peoples R China
[2] Sun Yat Sen Univ, Instrumental Anal & Res Ctr, Guangzhou 510275, Peoples R China
[3] Chinese Acad Sci, Inst Organ Chem, Chengdu 610041, Peoples R China
[4] Sun Yat Sen Univ, Minist Educ, Key Lab Gene Engn, Guangzhou 510275, Peoples R China
来源：
INORGANIC CHEMISTRY COMMUNICATIONS | 2004年 / 7卷 / 06期
基金：
中国国家自然科学基金;
关键词：
acyclic complex; acyclic ligand; copper(II) complex; DNA cleavage;
D O I：
10.1016/j.inoche.2004.04.014
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A novel acyclic copper complex of Cu(L)(H2O) (H2L=N,N'-1,2-ethanediyl-bis[N-(4-methoxyphenyl)methylglycine]) has been synthesized and structurally characterized by means of X-ray single crystal diffraction. Interestingly, this Cu(II) complex has been found to cleave supercoiled DNA (pBR 322) to nicked and linear forms in aerobic condition. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：803 / 805
页数：3
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