Overview of RAW264.7 for osteoclastogensis study: Phenotype and stimuli

被引：148

作者：

Kong, Lingbo ^{[1
]}

Smith, Wanli ^{[2
]}

Hao, Dingjun ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Honghui Hosp, Sch Med, Dept Spine, Xian, Shaanxi, Peoples R China

[2] Johns Hopkins Univ, Dept Neurosci, Baltimore, MD USA

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2019年 / 23卷 / 05期

基金：

中国博士后科学基金;

关键词：

bone marrow macrophage; LPS; osteoclast; phenotype; RANKL; RAW264.7; TNF-a; NF-KAPPA-B; NITRIC-OXIDE SYNTHASE; LARGE GREATER-THAN-OR-EQUAL-TO-10 NUCLEI; GROWTH-FACTOR-BETA; M-CSF EXPRESSION; TNF-ALPHA; RECEPTOR ACTIVATOR; BONE-MARROW; MESSENGER-RNA; CELL-LINES;

D O I：

10.1111/jcmm.14277

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Bone homeostasis is preserved by the balance of maintaining between the activity of osteogenesis and osteoclastogenesis. However, investigations for the osteoclastogenesis were hampered by considerable difficulties associated with isolating and culturing osteoclast in vivo. As the alternative, stimuli-induced osteoclasts formation from RAW264.7 cells (RAW-OCs) have gain its importance for extensively osteoclastogenic study of bone diseases, such as rheumatoid arthritis, osteoporosis, osteolysis and periodontitis. However, considering the RAW-OCs have not yet been well-characterized and RAW264.7 cells are polymorphic because of a diverse phenotype of the individual cells comprising this cell linage, and different fate associated with various stimuli contributions. Thus, in present study, we provide an overview for current knowledge of the phenotype of RAW264.7 cells, as well as the current understanding of the complicated interactions between various stimuli and RAW-OCs in the light of the recent progress.

引用

页码：3077 / 3087

页数：11

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