Circadian Rhythm in Rest and Activity: A Biological Correlate of Quality of Life and a Predictor of Survival in Patients with Metastatic Colorectal Cancer

被引：176

作者：

Innominato, Pasquale F. ^{[2
,3
,6
]}

Focan, Christian ^{[4
]}

Gorlia, Thierry ^{[5
]}

Moreau, Thierry ^{[7
]}

Garufi, Carlo ^{[8
]}

Waterhouse, Jim ^{[9
]}

Giacchetti, Sylvie ^{[2
,3
,6
]}

Coudert, Bruno ^{[10
]}

Iacobelli, Stefano ^{[11
]}

Genet, Dominique ^{[12
]}

Tampellini, Marco ^{[13
]}

Chollet, Philippe ^{[14
]}

Lentz, Marie-Ange ^{[5
]}

Mormont, Marie-Christine ^{[2
]}

Levi, Francis ^{[2
,3
,6
]}

Bjarnason, Georg A. ^{[1
]}

机构：

[1] Sunnybrook Odette Canc Ctr, Toronto, ON M4N 3M5, Canada

[2] INSERM, Biol Rhythms & Canc U776, Villejuif, France

[3] Hop Paul Brousse, AP HP, Chronotherapy Unit, Dept Oncol, Villejuif, France

[4] CHC Clin St Joseph, Liege, Belgium

[5] European Org Res Treatment Canc, Ctr Data, AISBL IVZW, Brussels, Belgium

[6] Univ Paris 11, UMR S0776, Orsay, France

[7] INSERM, Res Epidemiol & Biostat U780, Villejuif, France

[8] Ist Regina Elena, I-00161 Rome, Italy

[9] Liverpool John Moores Univ, Res Inst Sport & Exercise Sci, Liverpool L3 5UX, Merseyside, England

[10] Ctr Georges Francois Leclerc, Dijon, France

[11] Univ G dAnnunzio, Sch Med, Dept Oncol & Neurosci, Chieti, Italy

[12] CHU Dupuytren, Med Oncol Serv, Limoges, France

[13] Osped San Luigi Gonzaga, Orbassano, Italy

[14] Ctr Jean Perrin, Clermont Ferrand, France

来源：

CANCER RESEARCH | 2009年 / 69卷 / 11期

关键词：

NIGHT-SHIFT WORK; EUROPEAN-ORGANIZATION; JET-LAG; SLEEP; FATIGUE; HEALTH; RISK; CHEMOTHERAPY; HEMOGLOBIN; DISRUPTION;

D O I：

10.1158/0008-5472.CAN-08-4747

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The rest-activity circadian rhythm (CircAct) reflects the function of the circadian timing system. In a prior single-institution study, the extent of CircAct perturbation independently predicted for survival and tumor response in 192 patients receiving chemotherapy for metastatic colorectal cancer. Moreover, the main CircAct parameters correlated with several health-related quality of life (HRQoL) scales. In this prospective study, we attempted to extend these results to an independent cohort of chemotherapy-naive metastatic colorectal cancer patients participating in an international randomized phase III trial (European Organisation for Research and Treatment of Cancer 05963). Patients were randomized to receive chronomodulated or conventional infusion of 5-fluorouracil, leucovorin, and oxaliplatin as first-line treatment for metastatic colorectal cancer. Patients from nine institutions completed the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-C30 and wore a wrist accelerometer (actigraph) for 3 days before chemotherapy delivery. Two validated parameters (I<O and r24) were used to estimate CircAct. Of 130 patients with baseline CircAct assessments, 96 had baseline HRQoL data. I<O was confirmed to correlate with global quality of life, physical functioning, social functioning, fatigue, and appetite loss (r > |0.25|; P < 0.01). I<O further independently predicted for overall survival with a hazard ratio of 0.94 (P < 0.0001). The associations between CircAct parameters, HRQoL, and survival, which were shown in this international study involving previously untreated metastatic colorectal cancer patients, confirm prior single-institution findings in mostly pretreated metastatic colorectal cancer patients. The circadian timing system constitutes a novel therapeutic target. Interventions that normalize circadian timing system dysfunction may affect quality of life and survival in cancer patients. [Cancer Res 2009;69(11):4700-7]

引用

页码：4700 / 4707

页数：8

共 51 条

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