WS2 nanosheet as a new photosensitizer carrier for combined photodynamic and photothermal therapy of cancer cells

被引：294

作者：

Yong, Yuan ^{[1
]}

Zhou, Liangjun ^{[1
,3
]}

Gu, Zhanjun ^{[1
]}

Yan, Liang ^{[1
]}

Tian, Gan ^{[1
,4
]}

Zheng, Xiaopeng ^{[1
,3
]}

Liu, Xiaodong ^{[5
]}

Zhang, Xiao ^{[1
,2
]}

Shi, Junxin ^{[1
,6
]}

Cong, Wenshu ^{[1
]}

Yin, Wenyan ^{[1
]}

Zhao, Yuliang ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Inst High Energy Phys, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China

[2] Natl Ctr Nanosci & Technol China, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

[3] Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China

[4] Sichuan Univ, Coll Chem, Chengdu 610064, Peoples R China

[5] Yanshan Univ, Coll Environm & Chem Engn, Qinhuangdao 066004, Peoples R China

[6] Huaqiao Univ, Coll Mat Sci & Engn, Dept Mat Phys & Chem, Xiamen 361021, Peoples R China

来源：

NANOSCALE | 2014年 / 6卷 / 17期

基金：

中国国家自然科学基金;

关键词：

UP-CONVERSION NANOPARTICLES; WALLED CARBON NANOTUBES; IRON-OXIDE NANOCUBES; METHYLENE-BLUE; DRUG; ABLATION; DELIVERY; AGENT; CHEMOTHERAPY; NANOPROBES;

D O I：

10.1039/c4nr02453b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have developed a simple and efficient strategy to fabricate WS2 nanosheets with low toxicity and good water solubility via a liquid exfoliation method by using H2SO4 intercalation and ultrasonication. The as-prepared WS2 nanosheets were employed not only as an NIR absorbing agent for photothermal therapy (PTT) but also as a photosensitizer (PS) carrier for photodynamic therapy (PDT) due to their sheet like structure that offers large surface area to load PS molecules. Moreover, singlet-oxygen generation of the PSs-WS2 complex could be finely controlled by NIR irradiation that could manipulate the PSs release behavior from WS2 nanosheets. The synergistic anti-tumor effect of WS2 nanosheets mediated PDT-PTT was also evaluated carefully and the results clearly showed that the efficacy of combined PDT-PTT treatment of cancer cells is significantly higher than those of PDT-only and PTT-only treatment, indicating enhanced efficiency of the combined therapeutic system. In addition, the WS2 could be used as a computed tomography (CT) contrast agent for bio-imaging since W atoms have strong X-ray attenuation ability, making them a multifunctional theranostic platform for simultaneous imaging-guided diagnosis and therapy.

引用

页码：10394 / 10403

页数：10

共 47 条

[11] Copper Selenide Nanosnakes: Bovine Serum Albumin-Assisted Room Temperature Controllable Synthesis and Characterization [J].

Huang, Peng ;

Kong, Yifei ;

Li, Zhiming ;

Gao, Feng ;

Cui, Daxiang .

NANOSCALE RESEARCH LETTERS, 2010, 5 (06) :949-956

[12] Gold Nanorod-Photosensitizer Complex for Near-Infrared Fluorescence Imaging and Photodynamic/Photothermal Therapy In Vivo [J].

Jang, Boseung ;

Park, Jin-Young ;

Tung, Ching-Hsuan ;

Kim, In-Hoo ;

Choi, Yongdoo .

ACS NANO, 2011, 5 (02) :1086-1094

[13] Facile Synthesis and Intraparticle Self-Catalytic Oxidation of Dextran-Coated Hollow Au-Ag Nanoshell and Its Application for Chemo-Thermotherapy [J].

Jang, Hongje ;

Kim, Young-Kwan ;

Huh, Hyun ;

Min, Dal-Hee .

ACS NANO, 2014, 8 (01) :467-475

[14] Gold nanoparticles enhance methylene blue-induced photodynamic therapy: a novel therapeutic approach to inhibit Candida albicans biofilm [J].

Khan, Shakir ;

Alam, Fahad ;

Azam, Ameer ;

Khan, Asad U. .

INTERNATIONAL JOURNAL OF NANOMEDICINE, 2012, 7 :3245-3257

[15] Organically modified silica nanoparticles co-encapsulating photosensitizing drug and aggregation-enhanced two-photon absorbing fluorescent dye aggregates for two-photon photodynamic therapy [J].

Kim, Sehoon ;

Ohulchanskyy, Tymish Y. ;

Pudavar, Haridas E. ;

Pandey, Ravindra K. ;

Prasad, Paras N. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (09) :2669-2675

[16] Targeted near-IR hybrid magnetic nanoparticles for in vivo cancer therapy and imaging [J].

Kirui, Dickson K. ;

Khalidov, Ildar ;

Wang, Yi ;

Batt, Carl A. .

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2013, 9 (05) :702-711

[17] RGD-Conjugated Dendrimer-Modified Gold Nanorods for in Vivo Tumor Targeting and Photothermal Therapy [J].

Li, Zhiming ;

Huang, Peng ;

Zhang, Xuejun ;

Lin, Jing ;

Yang, Sen ;

Liu, Bing ;

Gao, Feng ;

Xi, Peng ;

Ren, Qiushi ;

Cui, Daxiang .

MOLECULAR PHARMACEUTICS, 2010, 7 (01) :94-104

[18] Photosensitizer-Loaded Gold Vesicles with Strong Plasmonic Coupling Effect for Imaging-Guided Photothermal/Photodynamic Therapy [J].

Lin, Jing ;

Wang, Shouju ;

Huang, Peng ;

Wang, Zhe ;

Chen, Shouhui ;

Niu, Gang ;

Li, Wanwan ;

He, Jie ;

Cui, Daxiang ;

Lu, Guangming ;

Chen, Xiaoyuan ;

Nie, Zhihong .

ACS NANO, 2013, 7 (06) :5320-5329

[19] Drug Delivery with PEGylated MoS2 Nano-sheets for Combined Photothermal and Chemotherapy of Cancer [J].

Liu, Teng ;

Wang, Chao ;

Gu, Xing ;

Gong, Hua ;

Cheng, Liang ;

Shi, Xiaoze ;

Feng, Liangzhu ;

Sun, Baoquan ;

Liu, Zhuang .

ADVANCED MATERIALS, 2014, 26 (21) :3433-3440

[20] Optimization of surface chemistry on single-walled carbon nanotubes for in vivo photothermal ablation of tumors [J].

Liu, Xiaowen ;

Tao, Huiquan ;

Yang, Kai ;

Zhang, Shuai ;

Lee, Shuit-Tong ;

Liu, Zhuang .

BIOMATERIALS, 2011, 32 (01) :144-151

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