WS2 nanosheet as a new photosensitizer carrier for combined photodynamic and photothermal therapy of cancer cells

被引：294

作者：

Yong, Yuan ^{[1
]}

Zhou, Liangjun ^{[1
,3
]}

Gu, Zhanjun ^{[1
]}

Yan, Liang ^{[1
]}

Tian, Gan ^{[1
,4
]}

Zheng, Xiaopeng ^{[1
,3
]}

Liu, Xiaodong ^{[5
]}

Zhang, Xiao ^{[1
,2
]}

Shi, Junxin ^{[1
,6
]}

Cong, Wenshu ^{[1
]}

Yin, Wenyan ^{[1
]}

Zhao, Yuliang ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Inst High Energy Phys, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China

[2] Natl Ctr Nanosci & Technol China, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

[3] Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China

[4] Sichuan Univ, Coll Chem, Chengdu 610064, Peoples R China

[5] Yanshan Univ, Coll Environm & Chem Engn, Qinhuangdao 066004, Peoples R China

[6] Huaqiao Univ, Coll Mat Sci & Engn, Dept Mat Phys & Chem, Xiamen 361021, Peoples R China

来源：

NANOSCALE | 2014年 / 6卷 / 17期

基金：

中国国家自然科学基金;

关键词：

UP-CONVERSION NANOPARTICLES; WALLED CARBON NANOTUBES; IRON-OXIDE NANOCUBES; METHYLENE-BLUE; DRUG; ABLATION; DELIVERY; AGENT; CHEMOTHERAPY; NANOPROBES;

D O I：

10.1039/c4nr02453b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have developed a simple and efficient strategy to fabricate WS2 nanosheets with low toxicity and good water solubility via a liquid exfoliation method by using H2SO4 intercalation and ultrasonication. The as-prepared WS2 nanosheets were employed not only as an NIR absorbing agent for photothermal therapy (PTT) but also as a photosensitizer (PS) carrier for photodynamic therapy (PDT) due to their sheet like structure that offers large surface area to load PS molecules. Moreover, singlet-oxygen generation of the PSs-WS2 complex could be finely controlled by NIR irradiation that could manipulate the PSs release behavior from WS2 nanosheets. The synergistic anti-tumor effect of WS2 nanosheets mediated PDT-PTT was also evaluated carefully and the results clearly showed that the efficacy of combined PDT-PTT treatment of cancer cells is significantly higher than those of PDT-only and PTT-only treatment, indicating enhanced efficiency of the combined therapeutic system. In addition, the WS2 could be used as a computed tomography (CT) contrast agent for bio-imaging since W atoms have strong X-ray attenuation ability, making them a multifunctional theranostic platform for simultaneous imaging-guided diagnosis and therapy.

引用

页码：10394 / 10403

页数：10

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