Fasting and Non-Fasting Triglycerides in Patients With Acute Ischemic Stroke

被引：2

作者：

Kim, Jun Yup ^{[1
]}

Lee, Keon-Joo ^{[1
,9
]}

Kang, Jihoon ^{[1
]}

Kim, Beom Joon ^{[1
]}

Han, Moon-Ku ^{[1
]}

Kang, Kyusik ^{[2
]}

Park, Jong-Moo ^{[3
]}

Park, Tai Hwan ^{[4
]}

Park, Hong-Kyun ^{[5
]}

Cho, Yong-Jin ^{[5
]}

Hong, Keun-Sik ^{[5
]}

Lee, Kyung Bok ^{[6
]}

Jang, Myung Suk ^{[1
]}

Lee, Ji Sung ^{[7
]}

Lee, Juneyoung ^{[8
]}

Bae, Hee-Joon ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Med, Bundang Hosp, Dept Neurol, 82 Gumi Ro 173 Beon Gil, Seongnam 13620, South Korea

[2] Eulji Univ, Nowon Eulji Med Ctr, Dept Neurol, Sch Med, Seoul, South Korea

[3] Eulji Univ, Uijeongbu Eulji Med Ctr, Dept Neurol, Uijongbu, South Korea

[4] Seoul Med Ctr, Dept Neurol, Seoul, South Korea

[5] Inje Univ, Dept Neurol, Ilsan Paik Hosp, Goyang, South Korea

[6] Soonchunhyang Univ, Soonchunhyang Univ Hosp, Dept Neurol, Coll Med, Seoul, South Korea

[7] Asan Med Ctr, Clin Res Ctr, Asan Inst Life Sci, Seoul, South Korea

[8] Korea Univ, Dept Biostat, Coll Med, Seoul, South Korea

[9] Korea Univ, Guro Hosp, Dept Neurol, Seoul, South Korea

来源：

JOURNAL OF KOREAN MEDICAL SCIENCE | 2022年 / 37卷 / 13期

关键词：

Triglycerides; Postprandial; Fasting Triglycerides; Non-fasting Triglycerides; Ischemic Stroke; RECURRENT STROKE; RISK; LIPOPROTEINS; ASSOCIATION; CHOLESTEROL; HYPERTRIGLYCERIDEMIA; MANAGEMENT; PREDICTOR; INCREASE; OUTCOMES;

D O I：

10.3346/jkms.2022.37.e100

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Clinical implications of elevated fasting triglycerides (FTGs) and non-fasting triglycerides (NFTGs) in acute ischemic stroke (AIS) remain unknown. We aimed to elucidate the correlation and clinical significance of FTG and NFTG levels in AIS patients. Methods: Using a multicenter prospective stroke registry, we identified AIS patients hospitalized within 24 hours of onset with available NFTG results. The primary outcome was a composite of stroke recurrence, myocardial infarction, and all-cause mortality up to one year. Results: This study analyzed 2,176 patients. The prevalence of fasting and non-fasting hypertriglyceridemia was 11.5% and 24.6%, respectively. Multivariate analysis revealed that younger age, diabetes, higher body mass index and initial systolic blood pressure were independently associated with both fasting and non-fasting hypertriglyceridemia (all P < 0.05). Patients with higher quartiles of NFTG were more likely to be male, younger, ever smokers, diabetic, and have family histories of premature coronary heart disease and stroke (all P < 0.05). Similar tendencies were observed for FTG. The composite outcome was not associated with FTG or NFTG quartiles. Conclusion: The fasting and non-fasting hypertriglyceridemia were prevalent in AIS patients and showed similar clinical characteristics and outcomes. High FTG and NFTG levels were not associated with occurrence of subsequent clinical events up to one year.

引用

页数：11