Long Noncoding RNA-Sox2OT Knockdown Alleviates Diabetes Mellitus-Induced Retinal Ganglion Cell (RGC) injury

被引：81

作者：

Li, Chao-Peng ^{[1
]}

Wang, Shu-Hong ^{[1
]}

Wang, Wen-Qi ^{[1
]}

Song, Shu-Guang ^{[1
]}

Liu, Xiu-Ming ^{[1
]}

机构：

[1] Nanjing Med Univ, Huai An Peoples Hosp 1, Huaian, Jiangsu, Peoples R China

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 2017年 / 37卷 / 02期

关键词：

Diabetic retinopathy; Retinal ganglion cell (RGC); Long noncoding RNA; NRF2/HO-1; signaling; NEURAL APOPTOSIS; EXPRESSION; RNAS; DYSFUNCTION; DISEASE; MODEL;

D O I：

10.1007/s10571-016-0380-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Retinal ganglion cell (RGC) injury is one of the important pathological features of diabetes-induced retinal neurodegeneration. Increasing attention has been paid to find strategies for protecting against RGC injury. Long noncoding RNAs (lncRNAs) have emerged as the key regulators of many cell functions. Here, we show that Sox2OT expression is significantly down-regulated in the retinas of STZ-induced diabetic mice and in the RGCs upon high glucose or oxidative stress. SOX2OT knockdown protects RGCs against high glucose-induced injury in vitro. Moreover, Sox2OT knockdown plays a neuroprotective role in diabetes-related retinal neurodegeneration in vivo. Sox2OT knockdown could regulate oxidative stress response in RGCs and diabetic mouse retinas. Sox2OT knockdown plays an anti-oxidative role via regulating NRF2/HO-1 signaling activity. Taken together, Sox2OT knockdown may be a therapeutic strategy for the prevention and treatment of diabetes-induced retinal neurodegeneration.

引用

页码：361 / 369

页数：9

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