Circulating Avian Influenza Viruses Closely Related to the 1918 Virus Have Pandemic Potential

被引：57

作者：

Watanabe, Tokiko ^{[1
,2
]}

Zhong, Gongxun ^{[1
]}

Russell, Colin A. ^{[3
]}

Nakajima, Noriko ^{[4
]}

Hatta, Masato ^{[1
]}

Hanson, Anthony ^{[1
]}

McBride, Ryan ^{[5
]}

Burke, David F. ^{[6
]}

Takahashi, Kenta ^{[4
]}

Fukuyama, Satoshi ^{[2
]}

Tomita, Yuriko ^{[2
]}

Maher, Eileen A. ^{[1
]}

Watanabe, Shinji ^{[2
,7
]}

Imai, Masaki ^{[8
,9
]}

Neumann, Gabriele ^{[1
]}

Hasegawa, Hideki ^{[4
]}

Paulson, James C. ^{[5
]}

Smith, Derek J. ^{[6
]}

Kawaoka, Yoshihiro ^{[1
,2
,10
,11
]}

机构：

[1] Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Madison, WI 53711 USA

[2] Japan Sci & Technol Agcy, ERATO Infect Induced Host Responses Project, Saitama 3320012, Japan

[3] Univ Cambridge, Dept Vet Med, Cambridge CB3 0ES, England

[4] Natl Inst Infect Dis, Dept Pathol, Shinjuku Ku, Tokyo 1628640, Japan

[5] Scripps Res Inst, Dept Cell & Mol Biol, La Jolla, CA 92037 USA

[6] Univ Cambridge, Dept Zool, Cambridge CB2 3EJ, England

[7] Miyazaki Univ, Dept Vet Sci, Lab Vet Microbiol, Miyazaki 8892192, Japan

[8] Iwate Univ, Fac Agr, Dept Vet Med, Morioka, Iwate 0208550, Japan

[9] Natl Inst Infect Dis, Influenza Virus Res Ctr, Tokyo 2080011, Japan

[10] Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Div Virol, Tokyo 1088639, Japan

[11] Univ Tokyo, Inst Med Sci, Int Res Ctr Infect Dis, Dept Special Pathogens, Tokyo 1088639, Japan

来源：

CELL HOST & MICROBE | 2014年 / 15卷 / 06期

基金：

日本科学技术振兴机构;

关键词：

POLYMERASE SUBUNIT PB2; A VIRUSES; RECEPTOR SPECIFICITY; AIRBORNE TRANSMISSION; MOLECULAR-BASIS; HOST-RANGE; HEMAGGLUTININ; REPLICATION; FERRETS; PATHOGENICITY;

D O I：

10.1016/j.chom.2014.05.006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Wild birds harbor a large gene pool of influenza A viruses that have the potential to cause influenza pandemics. Foreseeing and understanding this potential is important for effective surveillance. Our phylogenetic and geographic analyses revealed the global prevalence of avian influenza virus genes whose proteins differ only a few amino acids from the 1918 pandemic influenza virus, suggesting that 1918-like pandemic viruses may emerge in the future. To assess this risk, we generated and characterized a virus composed of avian influenza viral segments with high homology to the 1918 virus. This virus exhibited pathogenicity in mice and ferrets higher than that in an authentic avian influenza virus. Further, acquisition of seven amino acid substitutions in the viral polymerases and the hemagglutinin surface glycoprotein conferred respiratory droplet transmission to the 1918-like avian virus in ferrets, demonstrating that contemporary avian influenza viruses with 1918 virus-like proteins may have pandemic potential.

引用

页码：692 / 705

页数：14

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