Pancreatic lipase inhibitory stilbenoids from the roots of Vitis vinifera

被引：18

作者：

Kim, Young-Mog ^{[1
]}

Lee, Eun-Woo ^{[2
]}

Eom, Sung-Hwan ^{[1
]}

Kim, Tae Hoon ^{[3
]}

机构：

[1] Pukyong Natl Univ, Dept Food Sci & Technol, Pusan, South Korea

[2] Dong Eui Univ, Dept Life Sci & Biotechnol, Pusan, South Korea

[3] Daegu Haany Univ, Dept Herbal Med Pharmacol, Gyongsan, South Korea

来源：

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION | 2014年 / 65卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Obesity; pancreatic lipase; stilbenenoids; Vitis vinifera; wilsonol C; RESVERATROL; OLIGOSTILBENES;

D O I：

10.3109/09637486.2013.832172

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Bioassay-guided isolation of an aqueous methanolic extract of Vitis vinifera using pancreatic lipase inhibitory activity led to isolation of seven stilbenoids, wilsonol C (1), heyneanol A (2), ampelopsin A (3), pallidol A (4), cis-piceid (5), trans-piceid (6) and trans-resveratrol (7). The structures were established on the basis of NMR and MS spectroscopic data interpretation. All isolates were evaluated for their inhibitory effects on pancreatic lipase, and stilbenoid 1 exhibited potent inhibitory effect on pancreatic lipase with IC50 values of 6.7 +/- 0.7 mu M.

引用

页码：97 / 100

页数：4

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