The infection of CD4+ cells by HIV leads to the progressive destruction of CD4+ T lymphocytes and, after a severe reduction of CD4+ cells, to AIDS. The aim of the study was to investigate whether HIV-infected patients with CD4 cell counts <200 cells/mu l can suffer from symptoms of IgE-mediated allergy, produce allergen-specific IgE antibody responses and show boosts of allergen-specific IgE production. HIV-infected patients with CD4 counts <= 200 cells/mu l suffering from AIDS and from IgE-mediated allergy were studied. Allergy was diagnosed according to case history, physical examination, skin prick testing (SPT), and serological analyses including allergen microarrays. HIV infection was confirmed serologically and the disease was staged clinically. The predominant allergic symptoms in the studied patients were acute allergic rhinitis (73%) followed by asthma (27%) due to IgE-mediated mast cell activation whereas no late phase allergic symptoms such as atopic dermatitis, a mainly T cell-mediated skin manifestation, were found in patients suffering from AIDS. According to IgE serology allergies to house dust mites and grass pollen were most common besides IgE sensitizations to various food allergens. Interestingly, pollen allergen-specific IgE antibody levels in the patients with AIDS and in additional ten IgE-sensitized patients with HIV infections and low CD4 counts appeared to be boosted by seasonal allergen exposure and were not associated with CD4 counts. Our results indicate that secondary allergen-specific IgE production and IgE-mediated allergic inflammation do not require a fully functional CD4+ T lymphocyte repertoire.
机构:
Univ Western Sydney, Campbelltown Hosp, Penrith, NSW 1797, AustraliaUniv Western Sydney, Campbelltown Hosp, Penrith, NSW 1797, Australia
Katelaris, C. H.
Lee, B. W.
论文数: 0引用数: 0
h-index: 0
机构:
Natl Univ Singapore Hosp, Dept Paediat, Singapore 117548, SingaporeUniv Western Sydney, Campbelltown Hosp, Penrith, NSW 1797, Australia
Lee, B. W.
Potter, P. C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cape Town, Allergy Diagnost & Clin Res Unit, Lung Inst, ZA-7925 Cape Town, South AfricaUniv Western Sydney, Campbelltown Hosp, Penrith, NSW 1797, Australia
Potter, P. C.
Maspero, J. F.
论文数: 0引用数: 0
h-index: 0
机构:
Fdn Cidea, Buenos Aires, DF, ArgentinaUniv Western Sydney, Campbelltown Hosp, Penrith, NSW 1797, Australia
Maspero, J. F.
Cingi, C.
论文数: 0引用数: 0
h-index: 0
机构:
Osmangazi Univ, Dept Otorhinolaryngol, Fac Med, Eskisehir, TurkeyUniv Western Sydney, Campbelltown Hosp, Penrith, NSW 1797, Australia
Cingi, C.
Lopatin, A.
论文数: 0引用数: 0
h-index: 0
机构:
First State Med Univ, Clin Ear Nose & Throat Dis, Moscow, RussiaUniv Western Sydney, Campbelltown Hosp, Penrith, NSW 1797, Australia
Lopatin, A.
Saffer, M.
论文数: 0引用数: 0
h-index: 0
机构:
Complexo Hosp Santa Casa Porto Alegre, Porto Alegre, RS, BrazilUniv Western Sydney, Campbelltown Hosp, Penrith, NSW 1797, Australia
Saffer, M.
Xu, G.
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Allergy & Canc Ctr, Otorhinolarygol Hosp, Affiliated Hosp 1, Guangzhou 510275, Guangdong, Peoples R China
Sun Yat Sen Univ, Otorhinolaryngol Inst, Guangzhou 510275, Guangdong, Peoples R ChinaUniv Western Sydney, Campbelltown Hosp, Penrith, NSW 1797, Australia
Xu, G.
Walters, R. D.
论文数: 0引用数: 0
h-index: 0
机构:
GlaxoSmithKline, Asia Pacific Japan & Emerging Markets APJEM, Med Affairs, London, EnglandUniv Western Sydney, Campbelltown Hosp, Penrith, NSW 1797, Australia
机构:
Univ Western Sydney, Campbelltown Hosp, Penrith, NSW 1797, AustraliaUniv Western Sydney, Campbelltown Hosp, Penrith, NSW 1797, Australia
Katelaris, C. H.
Lee, B. W.
论文数: 0引用数: 0
h-index: 0
机构:
Natl Univ Singapore Hosp, Dept Paediat, Singapore 117548, SingaporeUniv Western Sydney, Campbelltown Hosp, Penrith, NSW 1797, Australia
Lee, B. W.
Potter, P. C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cape Town, Allergy Diagnost & Clin Res Unit, Lung Inst, ZA-7925 Cape Town, South AfricaUniv Western Sydney, Campbelltown Hosp, Penrith, NSW 1797, Australia
Potter, P. C.
Maspero, J. F.
论文数: 0引用数: 0
h-index: 0
机构:
Fdn Cidea, Buenos Aires, DF, ArgentinaUniv Western Sydney, Campbelltown Hosp, Penrith, NSW 1797, Australia
Maspero, J. F.
Cingi, C.
论文数: 0引用数: 0
h-index: 0
机构:
Osmangazi Univ, Dept Otorhinolaryngol, Fac Med, Eskisehir, TurkeyUniv Western Sydney, Campbelltown Hosp, Penrith, NSW 1797, Australia
Cingi, C.
Lopatin, A.
论文数: 0引用数: 0
h-index: 0
机构:
First State Med Univ, Clin Ear Nose & Throat Dis, Moscow, RussiaUniv Western Sydney, Campbelltown Hosp, Penrith, NSW 1797, Australia
Lopatin, A.
Saffer, M.
论文数: 0引用数: 0
h-index: 0
机构:
Complexo Hosp Santa Casa Porto Alegre, Porto Alegre, RS, BrazilUniv Western Sydney, Campbelltown Hosp, Penrith, NSW 1797, Australia
Saffer, M.
Xu, G.
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Allergy & Canc Ctr, Otorhinolarygol Hosp, Affiliated Hosp 1, Guangzhou 510275, Guangdong, Peoples R China
Sun Yat Sen Univ, Otorhinolaryngol Inst, Guangzhou 510275, Guangdong, Peoples R ChinaUniv Western Sydney, Campbelltown Hosp, Penrith, NSW 1797, Australia
Xu, G.
Walters, R. D.
论文数: 0引用数: 0
h-index: 0
机构:
GlaxoSmithKline, Asia Pacific Japan & Emerging Markets APJEM, Med Affairs, London, EnglandUniv Western Sydney, Campbelltown Hosp, Penrith, NSW 1797, Australia