Persistence of IgE-Associated Allergy and Allergen-Specific IgE despite CD4+T Cell Loss in AIDS

被引:13
作者
Marth, Katharina [1 ,2 ]
Wollmann, Eva [1 ]
Gallerano, Daniela [1 ]
Ndlovu, Portia [3 ]
Makupe, Ian [3 ]
Valenta, Rudolf [1 ,2 ]
Sibanda, Elopy [3 ]
机构
[1] Med Univ Vienna, Ctr Pathophysiol Infectiol & Immunol, Dept Pathophysiol & Allergy Res, Div Immunopathol, Vienna, Austria
[2] Med Univ Vienna, Ctr Pathophysiol Infectiol & Immunol, Dept Pathophysiol & Allergy Res, Christian Doppler Lab Allergy Res,Div Immunopatho, Vienna, Austria
[3] Asthma Allergy & Immune Dysfunct Clin, Harare, Zimbabwe
来源
PLOS ONE | 2014年 / 9卷 / 06期
基金
奥地利科学基金会;
关键词
SERUM IGE; HIV; SENSITIZATION; INFECTION; INDIVIDUALS; REACTIVITY; ADULTS; T(H)2;
D O I
10.1371/journal.pone.0097893
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The infection of CD4+ cells by HIV leads to the progressive destruction of CD4+ T lymphocytes and, after a severe reduction of CD4+ cells, to AIDS. The aim of the study was to investigate whether HIV-infected patients with CD4 cell counts <200 cells/mu l can suffer from symptoms of IgE-mediated allergy, produce allergen-specific IgE antibody responses and show boosts of allergen-specific IgE production. HIV-infected patients with CD4 counts <= 200 cells/mu l suffering from AIDS and from IgE-mediated allergy were studied. Allergy was diagnosed according to case history, physical examination, skin prick testing (SPT), and serological analyses including allergen microarrays. HIV infection was confirmed serologically and the disease was staged clinically. The predominant allergic symptoms in the studied patients were acute allergic rhinitis (73%) followed by asthma (27%) due to IgE-mediated mast cell activation whereas no late phase allergic symptoms such as atopic dermatitis, a mainly T cell-mediated skin manifestation, were found in patients suffering from AIDS. According to IgE serology allergies to house dust mites and grass pollen were most common besides IgE sensitizations to various food allergens. Interestingly, pollen allergen-specific IgE antibody levels in the patients with AIDS and in additional ten IgE-sensitized patients with HIV infections and low CD4 counts appeared to be boosted by seasonal allergen exposure and were not associated with CD4 counts. Our results indicate that secondary allergen-specific IgE production and IgE-mediated allergic inflammation do not require a fully functional CD4+ T lymphocyte repertoire.
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页数:7
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