Neonatal tolerance revisited: Turning on newborn T cells with dendritic cells

被引：634
作者：
Ridge, JP
Fuchs, EJ
Matzinger, P
机构：
[1] Lab. of Cell. and Molec. Immunology, National Institute of Allergy, Infect. Dis. Natl. Institutes Hlth., Bethesda
[2] Johns Hopkins Oncology Center, Baltimore
来源：
SCIENCE | 1996年 / 271卷 / 5256期
关键词：
D O I：
10.1126/science.271.5256.1723
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
For some time it has been thought that antigenic challenge in neonatal life is a tolerogenic rather than immunogenic event. Reexamination of the classic neonatal tolerance experiments of Billingham, Brent, and Medawar showed that tolerance is not an intrinsic property of the newborn immune system, but that the nature of the antigen-presenting cell determines whether the outcome is neonatal tolerance or immunization.
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页码：1723 / 1726
页数：4
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